Not provided
| ID | Type | Description | Link |
|---|---|---|---|
| Arnhem-Nijmegen 2012/357 | Other Identifier | Commissie Mensgebonden Onderzoek |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| Radboud University Medical Center | OTHER |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
In the present study, muscle perfusion will be studied before and after an oral glucose challenge following a fasting period.
Based on data from previous studies, this physiological response is blunted in obese subjects, and the investigators expect these responses to be restored when the glucose load is combined with tea or beetroot juice in obese, insulin resistant men.
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Tea | Experimental | Oral intake of tea containing 75 grams of glucose |
|
| Beet root | Experimental | Oral intake of beetroot juice containing 75 grams of glucose |
|
| Placebo | Placebo Comparator | Oral intake of 75 grams of glucose in water |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Tea | Other | Oral intake of tea containing 75 grams of glucose |
| |
| Beet root |
| Measure | Description | Time Frame |
|---|---|---|
| Vascular resistance | Vascular resistance (arm and leg) as obtained from venous occlusion plethysmography and corrected for blood pressure | Average of values obtained at 30, 60, 90, 120, 150 and 180 minutes after test product intake corrected for the value obtained at approximately 20 minutes before test product intake (baseline) |
| Measure | Description | Time Frame |
|---|---|---|
| echo-Doppler | Postprandial muscle blood flow (arm and leg) measured by echo-Doppler at the brachial artery and the superficial femoral artery | Approximately 20 minutes before (baseline) and 30, 60, 90, 120, 150 and 180 minutes after test product intake |
| Near-infrared spectroscopy |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Affiliation | Role |
|---|---|---|
| M Hopman, Prof DR | Radboud University Medical Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Radboud University Nijmegen Medical Centre | Nijmegen | Gelderland | 6500 HB | Netherlands |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 27182277 | Derived | Fuchs D, Nyakayiru J, Draijer R, Mulder TP, Hopman MT, Eijsvogels TM, Thijssen DH. Impact of flavonoid-rich black tea and beetroot juice on postprandial peripheral vascular resistance and glucose homeostasis in obese, insulin-resistant men: a randomized controlled trial. Nutr Metab (Lond). 2016 May 13;13:34. doi: 10.1186/s12986-016-0094-x. eCollection 2016. |
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D007333 | Insulin Resistance |
| D009765 | Obesity |
| ID | Term |
|---|---|
| D006946 | Hyperinsulinism |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
Not provided
Not provided
| ID | Term |
|---|---|
| D013662 | Tea |
| ID | Term |
|---|---|
| D028321 | Plant Preparations |
| D001688 | Biological Products |
| D045424 | Complex Mixtures |
| D001628 | Beverages |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Other |
Oral intake of beetroot juice containing 75 grams of glucose |
|
| Placebo | Other | Oral intake of 75 grams of glucose in water |
|
Postprandial muscle blood flow (arm) measured by near-infrared spectroscopy on the extensor carpi radialis brevis muscles of the forearm |
| Approximately 20 minutes before (baseline) and 30, 60, 90, 120, 150 and 180 minutes after test product intake |
| Glucose and insulin | Glucose and insulin in venous blood plasma | Approximately 20 minutes before (baseline) and 30, 60, 90, 120, 150 and 180 minutes after test product intake |
| Vascular resistance exploratory | Vascular resistance (arm and leg) as obtained from venous occlusion plethysmography and corrected for blood pressure as an exploratory parameter. | Approximately 20 minutes before (baseline) and 30, 60, 90, 120, 150 and 180 minutes after test product intake |
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D001835 | Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D000066888 |
| Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |
| D019602 | Food and Beverages |