Effects of Phytonutrients Upon Muscle Perfusion in Response to Feeding

A Pilot Study to Explore the Acute Effects of Phytonutrients Upon Muscle Microvascular Blood Flow (Perfusion) in Response to Feeding in Older Adults.

This is a random order cross over design trial to evaluate the efficacy of select nutritional ingredients on enhancing muscle perfusion in response to an acute meal stimulus.

Inclusion Criteria:

• Body mass index (BMI) 18-30 kg/m2
• Free from active metabolic disease
• Normotensive

Exclusion Criteria:

• Habitual gym use or formal exercise (more than once a week) or other routine strenuous physical activity
• Smokers
• Surgery within past 3 months
• Active cardiovascular disease
• Taking beta-adrenergic blocking agents
• Cerebrovascular disease:
• Active respiratory disease
• Active metabolic disease
• Active inflammatory bowel or renal disease
• Active Malignancy or until confirmed remission
• Clotting dysfunction
• History of DVT
• Significant musculoskeletal or neurological disorders
• Family history of early (<55y) death from cardiovascular disease
• Known sensitivity to Sonovue contrast agent
• Known allergy or intolerance to any of the study ingredients
• Current use of any of the study ingredients