This is a randomized, double-blinded, crossover study to evaluate muscle protein metabolism during fasting and feeding in healthy older subjects.

Inclusion Criteria:

• Age ≥ 60 and ≤ 75 years
• Body Mass Index (BMI) > 23.0 to < 30.0
• Ability (with or without the aid of an assistive device) to climb a flight of 10 stairs or walk an equivalent of 1 city block without assistance
• Currently not participating in a formal exercise or training program and agrees to refrain from intense physical activity from screening through the completion of the study.

Exclusion Criteria:

• Diagnosis of diabetes

• Active pursuit of weight loss

• Poorly controlled hypertension or hypotension

• Untreated hypothyroidism or hyperthyroidism

• Anemia or abnormally functioning kidneys or liver

• A significant cardiovascular event within ≤ 6 months; or stated history of congestive heart failure; or evidence of clinically active cardiovascular disease assessed during the screening EKG

• Peripheral arterial disease or other diseases that preclude proper limb blood flow

• Chronic, contagious, infectious disease

• Current infection or corticosteroid treatment within the last 3 months

• Clotting or bleeding disorders, stated history of Deep Vein Thrombosis (DVT) and/or a known hypercoagulable condition

• In condition deemed unsuitable for study based upon study physician assessment

• Surgery requiring >2 days of hospitalization in the last 3 weeks and/or planned elective surgery requiring >2 days of hospitalization during the course of the study

• Current active malignant disease or was treated within the last 6 months for cancer

• An amputee

• Obstruction of the gastrointestinal tract, inflammatory bowel disease, short bowel syndrome or other forms of gastrointestinal disease

• Diagnosed with, or has a history of severe dementia or delirium, eating disorder, history of significant neurological or psychiatric disorder, alcoholism, substance abuse

• Cannot refrain from taking

  • High doses of fish oil, or omega-3 supplements, or high doses of vitamin D
  • Medications/dietary supplements/herbals or substances that are considered anabolic, or reduce weight
  • Any pulmonary anti-inflammatory medication or bronchodilators on the day of and 48 hours prior to study visits 1 and 2
  • NSAIDS or acetaminophen on the day of and 48 hours prior to study visits 1 and 2

• Chronic use of nicotine

• Allergic or intolerant to any ingredient found in the study products