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| Name | Class |
|---|---|
| Centre Hospitalier Universitaire Vaudois | OTHER |
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The purpose of this study is to determine whether glucose-fructose intake during training increases lactate transport and oxidation and improve endurance performance.
The study will enroll 24 healthy male volunteers. After baseline assessment of lactate transport and endurance performance, subjects will be randomized to either a 3-week intervention arm in which they will train with glucose-fructose intake during training, or to a control arm (water during training). After this 3-week intervention, lactate transport and endurance performance will be assessed again.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Glucose-fructose | Experimental | Participants will take glucose-fructose drinks during training sessions |
|
| Water | Experimental | Participants will take only water during training sessions |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Glucose-fructose | Dietary Supplement | 0.8 g/h glucose and 0.5 g/h fructose during training |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in lactate transport | Measurement of lactate production, utilization, oxidation and clearance during a 90 min cycling exercise at 50% VO2 max (measured with 13C-lactate) | At baseline (before training) and after the 3-week training protocol |
| Measure | Description | Time Frame |
|---|---|---|
| Change in muscle monocarboxylate transporters (MCTs) expression and protein content | MCTs expression (mRNA) and protein content after muscle biopsy | At baseline (before training) and after the 3-week training protocol |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Luc Tappy, Pr | University of Lausanne | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Lausanne | Lausanne | Canton of Vaud | 1005 | Switzerland |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 20826630 | Background | Lecoultre V, Benoit R, Carrel G, Schutz Y, Millet GP, Tappy L, Schneiter P. Fructose and glucose co-ingestion during prolonged exercise increases lactate and glucose fluxes and oxidation compared with an equimolar intake of glucose. Am J Clin Nutr. 2010 Nov;92(5):1071-9. doi: 10.3945/ajcn.2010.29566. Epub 2010 Sep 8. |
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| ID | Term |
|---|---|
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D001519 | Behavior |
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| ID | Term |
|---|---|
| D014867 | Water |
| ID | Term |
|---|---|
| D006878 | Hydroxides |
| D000468 | Alkalies |
| D007287 | Inorganic Chemicals |
| D000838 | Anions |
| D007477 |
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| Water | Dietary Supplement | Only water intake during training |
|
| Ions |
| D004573 | Electrolytes |
| D010087 | Oxides |
| D017601 | Oxygen Compounds |