Effects of Fructose and Exercise on Hepatic Lipid Metabolism

Effects of a Weight Maintenance, High Fructose Diet and of Exercise on Hepatic Lipid Metabolism

8 healthy male volunteers will be studied each on 3 occasions, ie

• after 4 days on a weight maintenance diet containing 5% simple sugars + low physical activity
• after 4 days on a weight maintenance diet containing 30% fructose + low physical activity
• after 4 days on a weight maintenance diet containing 30% fructose + high physical activity At the end of each of these 3 periods, fructose induced hepatic de novo lipogenesis (13C palmitate synthesis in response to ingestion of a 13C fructose load) and plasma VLDL-triglyceride kinetics (measured with a bolus of 2H-labeled glycerol) will be measured

Inclusion Criteria:

• age between 18 and 30 years
• males
• BMI between 19 and 25
• low to moderate physical activity (< 3 sessions/week)

Exclusion Criteria:

• smoking
• consumption of alcohol>50g/week
• consumption of drugs or illicit substances
• food allergies