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This study is planned to investigate the relationship between duration of extracorporeal circulation and the extent of (acquired) platelet dysfunctions in patients undergoing cardiac surgery.
Patients undergoing complex cardiac surgery are planned to be included. At several intra- and postoperative measuring point, blood is drawn for multiple electrode aggregometry to investigate ex-vivo platelet aggregation as a surrogate for platelet function.
Transfusion rate of allogenic blood products as well as postoperative blood loss is planned to be recorded.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| cardiac surgery patients | cardiac surgery patients scheduled for elective complex cardiac surgery |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Multiple electrode aggregometry analyses (Multiple Electrode Aggregometry, Multiplate(R), Verum Diagnostica, Munich, Germany) | Device | ex vivo platelet aggregation at several intraoperative and postoperative measuring points. |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in arachidonic acid induced platelet aggregation as compared to baseline (before extracorporeal circulation) | Multiple Electrode aggregometry parameters | Baseline (before extracorporeal circulation) and 60, 90, 120, 150 and 180 minutes after extracorporal circulation as well as ad admission to ICU |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in Adenosin Diphosphate (ADP) and Thrombin induced platelet aggregation as compared to baseline (before extracorporeal circulation) | Multiple electrode aggregometry analyses | Baseline (before extracorporeal circulation) and 60, 90, 120, 150 and 180 minutes after extracorporal circulation as well as ad admission to ICU |
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Inclusion Criteria:
Exclusion Criteria:
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Cardiac surgery patients undergoing complex cardiac surgery (double valve, aortic surgery, combined - or redo procedures)
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| Name | Affiliation | Role |
|---|---|---|
| Christian F Weber, M.D. | Goethe University Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt, Germany | Principal Investigator |
| Christian Reyher, M.D. | Goethe University Frankfurt, Clinic for Anesthesiology, Theodor Stern Kai 7, 60590 Frankfurt, Germany | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Goethe - University | Frankfurt am Main | Hesse | 60322 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 19448196 | Background | Velik-Salchner C, Maier S, Innerhofer P, Kolbitsch C, Streif W, Mittermayr M, Praxmarer M, Fries D. An assessment of cardiopulmonary bypass-induced changes in platelet function using whole blood and classical light transmission aggregometry: the results of a pilot study. Anesth Analg. 2009 Jun;108(6):1747-54. doi: 10.1213/ane.0b013e3181a198ac. |
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