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| Name | Class |
|---|---|
| University of Aarhus | OTHER |
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The primary aim is to describe platelet function in adult patients treated with extracorporeal membrane oxygenation (ECMO). A clarification of the platelet function in these critically ill patients contributes to an understanding of the mechanisms underlying their coagulopathy.
The present study is a substudy to the study entitled; "Coagulopathy During Extracorporeal Membrane Oxygenation" (pending Clinical Trial ID number).
The knowledge of platelet function during extracorporeal membrane oxygenation (ECMO) remains sparse. In the present study, the aim is to investigate platelet function in adult patients treated with ECMO using flow cytometry. The investigators hypothesize that platelet function increases from day 1 to day 3 in patients treated with ECMO. The secondary aim is to investigate the association between platelet function and the incidence of bleeding episodes and thrombosis during ECMO treatment.
The present study is a substudy to the study entitled; "Coagulopathy During Extracorporeal Membrane Oxygenation" (pending Clinical Trial ID number).
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| Measure | Description | Time Frame |
|---|---|---|
| Changes in platelet function | Platelet function on day 3 compared with day 1 on ECMO. Measured by flow cytometry | Platelet function measured day 1 and day 3 on ECMO |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in platelet aggregation | Comparison of platelet aggregation measured by whole blood impedance aggregometry (Multiplate). | Platelet function measured every morning from day 1 to day 8 on ECMO (except weekends). |
| Immature platelet count |
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Inclusion Criteria:
Exclusion Criteria:
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Patients treated with ECMO at the Intensive Care Unit East, Aarhus University Hospital.
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| Name | Affiliation | Role |
|---|---|---|
| Camilla Mains Balle, Research fellow | Centre of Haemophilia and Thrombosis, Department of Clinical Biochemistry, Aarhus University Hospital | Principal Investigator |
| Anne-Mette Hvas, Professor, MD, PhD | Centre of Haemophilia and Thrombosis, Department of Clinical Biochemistry, Aarhus University Hospital | Study Chair |
| Anni Nørgaard Jeppesen, MD, PhD | Department of Anaesthesiology and Intensive Care Unit East, Aarhus University Hospital | Study Chair |
| Steffen Christensen, MD, PhD | Department of Anaesthesiology and Intensive Care Unit East, Aarhus University Hospital | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Centre of Haemophilia and Thrombosis, Department of Clinical Biochemistry, Aarhus University Hospital | Aarhus | 8000 | Denmark | |||
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Estimation of platelet turn-over measured by a blood analyzer (Sysmex)
| Measured every morning from day 1 to day 8 on ECMO (except weekends) |
| Platelet count | Estimation of platelet count measured by a blood analyzer (Sysmex) | Measured every morning from day 1 to day 8 on ECMO (except weekends) |
| Department of Anaesthesiology and Intensive Care Unit East, Aarhus University Hospital |
| Aarhus |
| 8000 |
| Denmark |