Quantification of Thrombocytes Number and Function in Patients Undergoing Prolonged Extracorporeal Circulation

Quantification of Thrombocytes Number and Function in Patients Undergoing Prolonged Extracorporeal Circulation for Cardiac Surgery

Prolonged extracorporeal circulation (ECC) for cardiac surgery results in coagulation abnormalities, most of which related to the direct, time dependent effect of the polymer tubing and the pump rollers on the thrombocytes. Significant evidence demonstrates the effect of the duration of cardiopulmonary bypass on thrombocytes number and function, as well as on postoperative coagulopathy

Quantification of the effect of ECC duration on blood coagulation and platelet number and function

• Observational study on 20 patients undergoing prolonged ECC
• Blood sampling every 30 minutes for platelet count, platelet adhesion markers and coagulation studies
• Blood test to be performed in Rambam Blood Bank Laboratory

Inclusion Criteria:

• adults over 18 yo
• scheduled for prolonged cardiac surgery requiring ECC time over 3 hours

Exclusion Criteria:

• documented coagulopathy
• antiplatelet therapy other then aspirin