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It has been suggested that betaine supplementation may improve muscle strength by increasing muscle creatine content. However, there is no data supporting this assumption. The investigators speculate that betaine supplementation could enhance intramuscular creatine content, which would result in strength improvements.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| creatine | Experimental | will receive creatine monohydrate (20g/d) throughout 10 days |
|
| betaine | Experimental | will receive betaine (2g/d) throughout 10 days |
|
| placebo (dextrose) | Placebo Comparator | will receive dextrose(20g/d)throughout 10 days. |
|
| creatine plus betaine | Active Comparator | will receive creatine (20g/d) plus betaine (2g/d) throughout 10 days |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| creatine | Dietary Supplement | 20g/d throughout 10 days |
| |
| betaine |
| Measure | Description | Time Frame |
|---|---|---|
| strength | after 10 days |
| Measure | Description | Time Frame |
|---|---|---|
| intramuscular creatine content | after 10 days |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Bruno Gualano, PhD | University of Sao Paulo | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Sao Paulo | São Paulo | São Paulo | 05508-030 | Brazil |
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| ID | Term |
|---|---|
| D003401 | Creatine |
| D001622 | Betaine |
| D005947 | Glucose |
| ID | Term |
|---|---|
| D006146 | Guanidines |
| D000578 | Amidines |
| D009930 | Organic Chemicals |
| D000596 | Amino Acids |
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| Dietary Supplement |
2g/d throughout 10 days |
|
| dextrose | Dietary Supplement | dextrose (placebo), 20 g/d throughout 10 days |
|
| creatine plus betaine | Dietary Supplement | creatine (20g/d) plus betaine (2g/d) throughout 10 days |
|
| D000602 |
| Amino Acids, Peptides, and Proteins |
| D050337 | Trimethyl Ammonium Compounds |
| D000644 | Quaternary Ammonium Compounds |
| D000588 | Amines |
| D009861 | Onium Compounds |
| D006601 | Hexoses |
| D009005 | Monosaccharides |
| D000073893 | Sugars |
| D002241 | Carbohydrates |