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| Name | Class |
|---|---|
| Iovate Health Sciences International Inc | INDUSTRY |
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The purpose is to compare the effects of bolus ingestion (5 grams) vs. intermittent ingestion (2 x 2.5 grams) of creatine supplementation vs. placebo for 21 days on measures of body composition (lean tissue mass-indicator of muscle mass, total body water) and muscle performance (i.e., power, strength, endurance).
Creatine is a naturally occurring compound produced in the liver and brain. Creatine can also be found in food products such as red meat and seafood or through commercially available manufactured creatine products (i.e. creatine supplementation).
Evidence-based research shows that creatine supplementation improves measures of body composition and muscle performance. However, the optimal creatine supplementation protocol to achieve these benefits is unknown.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Creatine Bolus | Experimental | (Serving 1: 5 grams of creatine monohydrate + 3 grams of placebo in the morning; Serving 2: 8 grams of placebo in the evening) for 21 days. |
|
| Creatine Intermittent | Experimental | (Serving 1: 2.5 grams of creatine monohydrate + 5.5 grams of placebo in the morning; Serving 2: 2.5 grams of creatine monohydrate + 5.5 grams of placebo in the evening) for 21 days. |
|
| Placebo | Placebo Comparator | (Servings 1: 8 grams of placebo in the morning; Serving 2: 8 grams of placebo in the evening) for 21 days. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Creatine | Dietary Supplement | Creatine monohydrate |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Whole-body lean mass (kg) | Bioelectrical impedance analysis | baseline, day 21 |
| Strength | 1-repetition maximum leg press and chest press (kg) | baseline, day 21 |
| Endurance | Repetitions to fatigue for leg press and chest press (total number) | baseline, day 21 |
| Hydration | Total body water (kg) using bioelectrical impedance analysis | baseline, day 21 |
| Power | Vertical Jump (cm) | baseline, day 21 |
| Power | Medicine Ball Throw (feet) | baseline, day 21 |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Darren Candow | Contact | 306-585-4906 | Darren.Candow@uregina.ca |
| Name | Affiliation | Role |
|---|---|---|
| Darren Candow | University of Regina | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Regina | Recruiting | Regina | Saskatchewan | S4S 0A2 | Canada |
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| ID | Term |
|---|---|
| D003401 | Creatine |
| ID | Term |
|---|---|
| D006146 | Guanidines |
| D000578 | Amidines |
| D009930 | Organic Chemicals |
| D000596 | Amino Acids |
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| Placebo |
| Dietary Supplement |
Maltodextrin |
|
| D000602 |
| Amino Acids, Peptides, and Proteins |