Double and Single Intrauterine Insemination In Controlled Ovarian Stimulation (COH) Cycles With Multifollicular Development

Our hypothesis is double insemination will improve pregnancy rates in coh cycles with more than one dominant follicles (>16mm).

Metaanalysis for the effects of double IUI demonstrates that effects of this procedure is not different from single IUI. It is known that nearly 25% of coh cycles is evident by monofollicular development.For this reason it is possible that this monofollicular cycles in the studies could decrease the effects of double IUI.

Inclusion criteria:

1. Patients with unexplained infertility or mild male factor infertility whom admitted to the COH+IUI programme in our infertility unit.
2. Female age <37 years old.
3. Baseline FSH <12 mIU/L
4. Total antral follicle count>6
5. During the first three cycles of COH+IUI
6. Minimum 2 follicles >16 mm at the day of HCG.

Primary outcome:

Ongoing pregnancy rates

Secondary outcomes:

The effects of different coh regimens (CC,FSH,CC+FSH)on the outcomes.

Inclusion Criteria:

• Unexplained and mild male factor infertile patients
• Minimum 2 follicles >16 mm at the day of HCG
• First 3 cycles

Exclusion Criteria:

• Basal FSH >12 mIU/L
• Total antral follicle count<6
• Severe male factor infertility