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Our hypothesis is double insemination will improve pregnancy rates in coh cycles with more than one dominant follicles (>16mm).
Metaanalysis for the effects of double IUI demonstrates that effects of this procedure is not different from single IUI. It is known that nearly 25% of coh cycles is evident by monofollicular development.For this reason it is possible that this monofollicular cycles in the studies could decrease the effects of double IUI.
Inclusion criteria:
Primary outcome:
Ongoing pregnancy rates
Secondary outcomes:
The effects of different coh regimens (CC,FSH,CC+FSH)on the outcomes.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Single IUI | Sham Comparator | Single IUI will be carried on after 36-38 hours of HCG administration |
|
| Double IUI | Active Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Intrauterine insemination (single) | Procedure | Single IUI after 36-38 hours of HCG |
|
| Measure | Description | Time Frame |
|---|---|---|
| ongoing pregnancy rates | pregnancy >12 weeks of gestation |
| Measure | Description | Time Frame |
|---|---|---|
| The effects of different coh regimens on outcomes | 14 days after IUI procedure |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Baskent University Medical Faculty Obstetric and Gynecelogy Department, Infertility and IVF unit | Adana | 01120 | Turkey (Türkiye) |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 20457669 | Derived | Bagis T, Haydardedeoglu B, Kilicdag EB, Cok T, Simsek E, Parlakgumus AH. Single versus double intrauterine insemination in multi-follicular ovarian hyperstimulation cycles: a randomized trial. Hum Reprod. 2010 Jul;25(7):1684-90. doi: 10.1093/humrep/deq112. Epub 2010 May 10. |
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| Double intrauterine insemination | Procedure | Double insemination after 18 and 40 hours of HCG administration. |
|
|
| ID | Term |
|---|---|
| D007246 | Infertility |
| ID | Term |
|---|---|
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
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| ID | Term |
|---|---|
| D012847 | Single Person |
| ID | Term |
|---|---|
| D017533 | Marital Status |
| D005191 | Family Characteristics |
| D003710 | Demography |
| D011154 | Population Characteristics |
| D012959 | Socioeconomic Factors |
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