Double Pick up in Poor Prognosis Women

Double Trigger and Ovum Retrieval vs. Conventional Antagonist Ovarian Stimulation Protocol in Poor Prognosis Women Undergoing IVF/ICSI: A Pilot Randomized Study

The purpose of this randomized pilot study is to compare the efficacy of double oocyte retrieval vs. conventional antagonist ovarian stimulation protocol in poor prognosis patients undergoing in vitro fertilization (IVF) or intra-cytoplasmic sperm injection (ICSI).

Inclusion Criteria:

• Age 25-40 years
• Body mass index (BMI) ≤ 35 and ≥ 19
• Antimüllerian hormone (AMH) level of ≤1.5 ng/mL or antral follicular count (AFC) of ≤6 follicles or ≤5 oocytes retrieved in a previous cycle following standard conventional ovarian stimulation.

Exclusion Criteria:

• Testicular sperm extraction
• History of > 3 three consecutive previous unsuccessful IVF cycles
• BMI >35 or <19
• Use of oral contraceptives <3 months before start of the treatment
• polycystic ovary syndrome (PCOS) according to the Rotterdam criteria
• Ovarian stimulation for pre-implantation genetic testing (PGT-A/M)
• Medical/social freezing
• In vitro maturation (IVM)
• History of untreated autoimmune, endocrine or metabolic disorders,
• Ovarian cystectomy or oophorectomy