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The study null hypothethesis is: intrauterine insemination (IUI) does not improve pregnancy rates in women with polycystic ovary syndrome. Infertile women with pcos will receive gonadotropins for ovarian stimulation and then randomize to either IUI or timed intercourse (TI)
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group A | Experimental | controlled ovarian hyperstimulation (COH) and intrauterine insemination (IUI) |
|
| Group B | No Intervention | Controlled ovarian hyperstimulation (COH)+ Timed Intercourse (TI) |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Intrauterine insemination (IUI) | Procedure | The male semen is obtained then processed by swim up technique and then introduced into the uterus by special catheter. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Live Birth Rate | 20 months |
| Measure | Description | Time Frame |
|---|---|---|
| Clinical pregnancy rate | 16 months |
| Measure | Description | Time Frame |
|---|---|---|
| multiple pregnancy rate | 20 months |
Inclusion Criteria:
- women who failed to get pregnant after 6 ovulation induction cycles with clomiphene citrate (cc) alone, despite of being ovulating with cc, having patent Fallopian tubes as confirmed by hysterosalpingography and their partners had fertile semen parameters according to criteria of World Health Organization (WHO 2010)
Exclusion Criteria:
male factor infertility
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| Name | Affiliation | Role |
|---|---|---|
| Ahmed Gibreel, MD | Mansoura University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Fertility Care Unit | Al Mansurah | Eldakahlia | 53111 | Egypt |
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| ID | Term |
|---|---|
| D007246 | Infertility |
| D011085 | Polycystic Ovary Syndrome |
| ID | Term |
|---|---|
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
| D010048 | Ovarian Cysts |
| D003560 | Cysts |
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|
| D009369 |
| Neoplasms |
| D010049 | Ovarian Diseases |
| D000291 | Adnexal Diseases |
| D005831 | Genital Diseases, Female |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D006058 | Gonadal Disorders |
| D004700 | Endocrine System Diseases |