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Difficulty in accrual of study subjects, small numbers of potential subjects
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2-octylcyanoacrylate (2-OCA) has been used extensively in clinical practice in trauma, plastic surgery, orthopaedic surgery, emergency medicine and paediatrics. Most studies on 2-OCA to date have focused on closure of short wounds, and only one has included closure of abdominal wounds in the context of general surgery. Here, the investigators will look at the results of closure of abdominal wounds in patients undergoing elective colectomies with 2-OCA, which is commercially available to us, versus closure with skin staples, which is the current standard technique of skin closure employed in the Department of Colorectal Surgery, Singapore General Hospital. The primary objective was to measure effectiveness of 2-OCA in 2 respects - the adequacy of wound healing and cosmesis, and the incidence of superficial wound infection.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Skin Staples | Active Comparator | Skin closure with skin staples |
|
| Dermabond | Experimental | Closure of abdominal wound with dermabond (2-octylcyanoacrylate) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Dermabond ProPen (2-octylcyanoacrylate) | Procedure | Application of 2 layers of Dermabond to abdominal wounds after closure of deep layers |
|
| Measure | Description | Time Frame |
|---|---|---|
| Wound healing | 3 months | |
| Patient satisfaction | 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| Superficial surgical site infections | 3 months | |
| Time taken for wound closure | Intraoperative |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Julian KP Ong, FRCSEd | Singapore General Hospital | Principal Investigator |
| Kok-Sun Ho, FRCS | Singapore General Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Singapore General Hospital | Singapore | 169608 | Singapore |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 9832658 | Background | Quinn J, Wells G, Sutcliffe T, Jarmuske M, Maw J, Stiell I, Johns P. Tissue adhesive versus suture wound repair at 1 year: randomized clinical trial correlating early, 3-month, and 1-year cosmetic outcome. Ann Emerg Med. 1998 Dec;32(6):645-9. doi: 10.1016/s0196-0644(98)70061-7. | |
| 15450839 | Background | Blondeel PN, Murphy JW, Debrosse D, Nix JC 3rd, Puls LE, Theodore N, Coulthard P. Closure of long surgical incisions with a new formulation of 2-octylcyanoacrylate tissue adhesive versus commercially available methods. Am J Surg. 2004 Sep;188(3):307-13. doi: 10.1016/j.amjsurg.2004.04.006. |
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| ID | Term |
|---|---|
| D014947 | Wounds and Injuries |
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| ID | Term |
|---|---|
| C100832 | octyl 2-cyanoacrylate |
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| Skin closure with skin staples | Procedure | Skin closure with skin staples |
|