The CALGB Leukemia Tissue Bank
The CALGB Leukemia Tissue Bank
As one of the nation's largest cooperative cancer treatment groups, the Alliance for Clinical Trials in Oncology (Alliance) is in a unique position to organize a Leukemia Tissue Bank. The member institutions diagnose hundreds of patients with leukemia or myelodysplastic syndrome each year, and uniformly treat these patients with chemotherapy regimens. The Alliance offers centralized data management for the clinical history, the classification of the leukemia and myelodysplastic syndrome, cytogenetics, flow cytometric analysis, treatment and follow-up. The highly skilled health care providers at each member institution are familiar with obtaining informed consent, completing data questionnaires and shipping specimens. There currently exists a central processing facility where samples are prepared for a variety of cellular and molecular studies. Hence, the patient resources, the health care providers, and a processing facility for a Leukemia Tissue Bank are all in place. What is needed, however, and is addressed in the current protocol, is a formal mechanism to procure bone marrow, blood and normal tissue from patients with hematologic malignancies who are to be enrolled on Alliance (Cancer and Leukemia Group B [CALGB]) treatment studies.
The objective of the study is to collect and store specimens from every newly diagnosed patient with acute or chronic leukemia or myelodysplastic syndrome (MDS) who are entered on a CALGB protocol for previously untreated patients. Bone marrow aspirate and blood specimens are obtained from patients at diagnosis, remission, or relapse and stored. Buccal smears are obtained at diagnosis, and DNA is extracted and preserved.
It was anticipated that the specimens collected under this protocol would be used by a large number of investigators. This protocol does not describe the details of each approved project (eg, eligibility age range).
Hartford, Connecticut 06102-5037, United States
Washington D.C., District of Columbia 20007, United States
Washington D.C., District of Columbia 20010, United States
Fort Lauderdale, Florida 33308, United States
Orlando, Florida 32803-1273, United States
Ottawa, Illinois 61350, United States
Peoria, Illinois 61615, United States
La Porte, Indiana 46350, United States
Baltimore, Maryland 21201, United States
Boston, Massachusetts 02115, United States
Columbia, Missouri 65203, United States
St Louis, Missouri 63110, United States
Grand Island, Nebraska 68803, United States
North Platte, Nebraska 69103, United States
Omaha, Nebraska 68198-6805, United States
Concord, New Hampshire 03301, United States
Lebanon, New Hampshire 03756-0002, United States
Manchester, New Hampshire 03102, United States
Voorhees Township, New Jersey 08043, United States
East Syracuse, New York 13057, United States
Lake Success, New York 11042, United States
Manhasset, New York 11030, United States
Chapel Hill, North Carolina 27599-7295, United States
Charlotte, North Carolina 28232-2861, United States
Charlotte, North Carolina 28233-3549, United States
Winston-Salem, North Carolina 27103, United States
Winston-Salem, North Carolina 27157-1096, United States
Columbus, Ohio 43210-1240, United States
Pittsburgh, Pennsylvania 15224-1791, United States
Burlington, Vermont 05401, United States
Martinsville, Virginia 24115, United States