This research study is collecting and storing samples of bone marrow and blood from patients with relapsed acute lymphoblastic leukemia or relapsed non-Hodgkin lymphoma. Collecting and storing samples of bone marrow and blood from patients with cancer to study in the laboratory may help doctors learn more about cancer and help predict the recurrence of cancer.

OBJECTIVES:

I. Establish a mechanism to bank specimens of tumor cells and host germline DNA from patients with acute lymphoblastic leukemia (ALL) at first and subsequent relapse.

II. Make these specimens available to qualified researchers to study the biology of ALL.

OUTLINE: This is a multicenter study.

Patients undergo collection of bone marrow and peripheral blood at diagnosis of relapse and/or at the end of the first month of treatment.

Patients are followed periodically for up to 10 years.

Inclusion Criteria:

• Diagnosis of acute lymphoblastic leukemia (ALL) or prior history of non-Hodgkin lymphoma

• In first or subsequent marrow relapse with ≥ 25% blasts in bone marrow and/or peripheral blood

• Bone marrow and/or peripheral blood samples (≥ 5 mL) required at the time of diagnosis of relapse

• No concurrent systemic antileukemic treatment administered for current relapse

  • Intrathecal chemotherapy allowed
  • On-therapy relapse allowed

Patient has ALL (or a prior history of Non Hodgkin lymphoma) at first or subsequent marrow relapse with greater than or equal to 25% blasts in the bone marrow and/or peripheral blood.