Tissue, Blood, and Body Fluid Sample Collection From Patients With Hematologic Cancer
Official Title
Tissue Procurement For Hematolymphoid Conditions
Acronym
Not provided
Organization
UNC Lineberger Comprehensive Cancer CenterOTHER
Status Module
Record Verification Date
Oct 2025
Overall Recruitment Status or Expanded Access Status
Recruiting
Last Known Status
Not provided
Delayed Posting
Not provided
Why Stopped
Not provided
Expanded Access Info
No
Start Date
Jul 2009
Primary Completion Date
Jul 2040Estimated
Completion Date
Jul 2040Estimated
First Submitted Date
Jun 3, 2010
First Submission Date that Met QC Criteria
Jun 3, 2010
First Posted Date
Jun 4, 2010Estimated
Results Waived
Not provided
Results First Submitted Date
Not provided
Results First Submitted that Met QC Criteria
Not provided
Results First Posted Date
Not provided
Certification/Extension (aka Delayed Results) First Submitted Date
Not provided
Certification/Extension First Submitted that Passed QC Review
Not provided
Certification/Extension First Posted Date
Not provided
Last Update Submitted Date
Oct 23, 2025
Last Update Posted Date
Oct 27, 2025Actual
Sponsor/Collaborators Module
Responsible Party, by Official Title
Sponsor
Lead Sponsor
UNC Lineberger Comprehensive Cancer CenterOTHER
Collaborators
Name
Class
National Cancer Institute (NCI)
NIH
Oversight Module
Has Data Monitoring Committee (DMC)
No
Is FDA Regulated Drug
Not provided
Is FDA Regulated Device
Not provided
Is Unapproved Device
Not provided
Pediatric Postmarket Surveillance of a Device Product
Not provided
Product Exported from US
Not provided
FDAAA801 Violation
Not provided
Description Module
Brief Summary
RATIONALE: Collecting and storing samples of tissue, blood, and body fluid from patients with cancer to study in the laboratory may help the study of cancer in the future.
PURPOSE: This research study is collecting and storing blood and tissue samples from patients being evaluated for hematologic cancer.
Detailed Description
OBJECTIVES:
Provide source of patient tissue, blood, and body fluid samples for ongoing diagnostic, prognostic, or immune-monitoring studies.
Support and enhance translational, clinical and basic research for Lineberger Comprehensive Cancer Center (LCCC) members (and non-members who have an LCCC member as sponsor and collaborator) with IRB-approved studies.
Maintain responsible and appropriate policies and procedures that ensure good patient care and responsible conduct of research.
Address medical and legal issues, and protect participant and patient privacy and confidentiality.
Provide a responsible and uniform mechanism for the integrated coordination of the hemato-pathologist and surgeon or hematology/oncology staff, researcher, and protocol office to obtain appropriate specimens for researchers.
Support young investigators to obtain pilot data for grant funding.
OUTLINE: Patients undergo tissue, blood, and body fluid collection during diagnostic or routine procedures for future correlative studies. Tissue samples may include, but are not limited to, lymph node or non-nodal biopsies, bone marrow biopsy and/or aspirate, blood and serum, and buccal swabs for germline DNA analysis.
Conditions Module
Conditions
Chronic Myeloproliferative Disorders
Leukemia
Lymphoma
Lymphoproliferative Disorder
Multiple Myeloma and Plasma Cell Neoplasm
Myelodysplastic Syndromes
Myelodysplastic/Myeloproliferative Neoplasms
Nonmalignant Neoplasm
Keywords
accelerated phase chronic myelogenous leukemia
acute undifferentiated leukemia
adult acute lymphoblastic leukemia in remission
adult acute myeloid leukemia in remission
adult acute myeloid leukemia with 11q23 (MLL) abnormalities
adult acute myeloid leukemia with inv(16)(p13;q22)
adult acute myeloid leukemia with t(15;17)(q22;q12)
adult acute myeloid leukemia with t(16;16)(p13;q22)
adult acute myeloid leukemia with t(8;21)(q22;q22)
All samples collected during routine clinical care.
cytology specimen collection procedure
Other
All Samples collected during routine clinical care.
Outcomes Module
Primary Outcomes
Measure
Description
Time Frame
Tissue, blood, and body fluid samples collection for ongoing diagnostic, prognostic, or immune-monitoring studies
30 years
Development of a centralized, quality-controlled, quality-assured facility for the procurement, processing, storage, and distribution of normal and malignant tissue specimens and corresponding blood specimens
30 years
Secondary Outcomes
Not provided
Other Outcomes
Not provided
Eligibility Module
Eligibility Criteria
DISEASE CHARACTERISTICS:
Diagnosis of abnormal hematopoietic/lymphoid cancer, including any of the following:
Acute myeloid leukemia
Acute lymphoblastic leukemia
Chronic myelogenous leukemia
Chronic lymphoid leukemia
Non-Hodgkin lymphoma
Hodgkin lymphoma
Myelodysplastic syndromes
Myeloproliferative disorders
Multiple myeloma
Waldenstrom macroglobulinemia
Aplastic anemia
Any other diseases that generate abnormalities in either number, function, or both of any cell type of hematolymphoid lineage
Patients who are being evaluated at the hematology/oncology clinics of the University of North Carolina Hospitals, at the stem cell transplant clinic, or in the hospital
PATIENT CHARACTERISTICS:
Not specified
PRIOR CONCURRENT THERAPY:
Not specified
Accepts Healthy Volunteers
No
Sex
All
Sex/Gender Based
Not provided
Sex/Gender Description
Not provided
Minimum Age
18 Years
Maximum Age
120 Years
Standard Ages
AdultOlder Adult
Study Population
Hematologic malignancies
Sampling Method
Non-Probability Sample
Contacts/Locations Module
Central Contacts
Name
Role
Phone
Extension
Email
Paul Armistead, MD
Contact
(919) 843-6847
paul_armistead@med.unc.edu
Overall Officials
Name
Affiliation
Role
Paul Armistead, MD
UNC Lineberger Comprehensive Cancer Center
Principal Investigator
Locations
Facility
Status
City
State
ZIP
Country
Contacts
Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill
Recruiting
Chapel Hill
North Carolina
27599-7295
United States
References Module
Citations
Not provided
See Also Links
Label
URL
Web address for UNC Lineberger Comprehensive Cancer Center