Central Lymphoma Repository Tissue Procurement Protocol
Central Lymphoma Repository Tissue Procurement Protocol
RATIONALE: Collecting and storing samples of tissue from patients with cancer to study in the laboratory may help doctors learn more about changes that may occur in DNA and identify biomarkers related to cancer. It may also help doctors learn how patients respond to treatment.
PURPOSE: This laboratory study is collecting, analyzing, and storing tissue samples from patients with non-Hodgkin's lymphoma.
OBJECTIVES:
OUTLINE: Patients are treated on the SWOG study on which they are enrolled.
Tissue samples obtained before treatment began are banked in a tissue repository.
Samples from patients with intermediate- or high-grade non-Hodgkin's lymphoma are analyzed by three-stage immunohistochemistry using monoclonal antibodies to B-cell antigens, T-cell antigens, immunoglobulins, CALLA, HLA-DR, anti-interleukin-2 receptor, and Ki-67 (for the proliferative index). Phenotype (immune marker status, proliferation status, and activation status) is correlated with response to treatment, relapse, and overall survival.
PROJECTED ACCRUAL: Approximately 495 patients will be accrued for this study.
DISEASE CHARACTERISTICS:
Registered on an active Southwest Oncology Group (SWOG)-coordinated treatment protocol for previously untreated non-Hodgkin's lymphoma
Adequate pretreatment diagnostic tissue available meeting the following requirements:
PATIENT CHARACTERISTICS:
PRIOR CONCURRENT THERAPY:
Hartford, Connecticut 06105, United States
Tampa, Florida 33612-9497, United States
Boise, Idaho 83712, United States
Beech Grove, Indiana 46107, United States
Wichita, Kansas 67214, United States
Lexington, Kentucky 40536-0093, United States
Shreveport, Louisiana 71130-3932, United States
Dearborn, Michigan 48123-2500, United States
Grosse Pointe Woods, Michigan 48236, United States
Billings, Montana 59102, United States
Missoula, Montana 59807, United States
Rochester, New York 14642, United States
Charlotte, North Carolina 28232-2861, United States
Charlotte, North Carolina 28233-3549, United States
Portland, Oregon 97213-2967, United States
Portland, Oregon 97239-3098, United States
Spartanburg, South Carolina 29303, United States
San Antonio, Texas 78229-3900, United States
Seattle, Washington 98122-4307, United States
Seattle, Washington 98195, United States