Diabetes and Metabolic Postprandial Responses

Comparison of Postprandial Metabolic Responses Between Type 2 Diabetic and Healthy Overweight Subjects

The aim of this trial was to compare postprandial metabolic response to glucose load in healthy overweight and type 2 diabetic subjects, by using glycemia, insulinemia, lipid profile, nutrient oxidation follow-up. Stable isotopes of glucose were used to assess postprandial total,exogenous and endogenous glucose kinetics.

Inclusion Criteria:

• Overweight or obese volunteers
• Healthy for one group nd type 2 diabetic for the second group
• Age between 30 and 65 years old
• Total cholesterol < or = 7 mmol/l and triglycerides < or = 4 mmol/l
• For diabetic group: treated by metformin and/or sulfonylurea and/or thiazolidinedione and HbA1c < 6%
• Stable weight over last 3 months
• Informed consent

Exclusion Criteria:

• No compliant subjects
• Participation in an other trial 2 months before starting this one
• Ward of court or under guardianship (sheltered adults)
• Person deprived of freedom by judicial or administrative decision
• Type 1 diabetes and type 2 diabetes treated bu insulin or acarbose
• Existence of a previously diagnosed pathology (other than type 2 diabetes)
• Previous gastro-intestinal pathology
• Treated by corticoids, anorexigens, weight loss medicines
• Alcoholism or severe tobacco consumption