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The study will compare plasma and urine post-prandial metabolomics after fat and glucose oral load according to lifestyle factors.
The metabolic response in plasma and urine, pre- and post-load tests in people with specific dietary lifestyles will be tested. This project will focus on fat and glucose induced changes of targeted metabolic pathways that have been related to diabetes and obesity risk.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Glucose tolerance test | Other | All participants will receive an oral standardized glucose tolerance test |
|
| Fat tolerance test | Other | The same participants will receive an oral standardized fat load test |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Glucose tolerance test | Other | Standardized oral glucose tolerance test (75 g oral glucose) and blood collection before and 2hrs after the glucose load |
|
| Measure | Description | Time Frame |
|---|---|---|
| Plasma levels of branched chain amino acid | Changes between baseline and 2 hours | |
| Plasma Trimethylamin N-oxide | Changes between baseline and 2 hours | |
| Plasma glucose level | Changes between baseline and 2 hours | |
| Plasma glucose | Changes between baseline and 2 hours | |
| Plasma level of acetyl-CoA | Changes between baseline and 2 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Plasma malonyl-CoA | Changes between baseline and 2 hours | |
| Plasma phosphatidylcholine | Changes between baseline and 2 hours | |
| Plasma insulin |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Rima Obeid | Universität des Saarlandes | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Saarland | Homburg | Saarland | 66424 | Germany |
will be decided at a later stage
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| ID | Term |
|---|---|
| D009765 | Obesity |
| D007333 | Insulin Resistance |
| ID | Term |
|---|---|
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
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| ID | Term |
|---|---|
| D005951 | Glucose Tolerance Test |
| ID | Term |
|---|---|
| D001774 | Blood Chemical Analysis |
| D019963 | Clinical Chemistry Tests |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
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| Fat tolerance test | Other | Oral fat tolerance will be provided to fasting participants and blood samples will be collected before and 4 hrs after the fat load. |
|
| Changes between baseline and 2 hours |
| Plasma leptin | Changes between baseline and 2 hours |
| Plasma Lactate | Changes between baseline and 2 hours |
| Plasma pyruvate | Changes between baseline and 2 hours |
| D001835 |
| Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D006946 | Hyperinsulinism |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D003933 | Diagnosis |
| D003940 | Diagnostic Techniques, Endocrine |
| D008919 | Investigative Techniques |