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| ID | Type | Description | Link |
|---|---|---|---|
| DB020-Single-site |
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Vibration response imaging (VRI) technology, provides a radiation-free dynamic image of the lung, by visualizing vibration energy emitted during the respiration cycle (lung sounds). Airflow in the lungs during the respiration cycle creates vibrations that propagate through the lung tissue; these vibrations are affected by the structural properties of the lungs and may vary in space, time and frequency. Moreover, any structural alteration, such as a bronchial obstruction or space occupying infiltration, is reflected in a corresponding modification of the vibration response.
As obstructions that occur in airways alter airflow, the VRI may provide additional lung function information prior to treatment for airway obstruction and during follow-up. Moreover, the VRI may provide the physician immediate evaluation of the improvement of air flow distribution, quantitative and qualitative measurements. Furthermore, the VRI is a non-invasive, radiation free procedure which is simple and doesn't require the level of patient effort required for lung function test and other evaluation.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Observation | Patients who present to the clinic with airway obstruction and who are designated to undergo intervention |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Vibration Response Imaging | Other | 12 seconds of recording lung sounds |
|
| Measure | Description | Time Frame |
|---|---|---|
| The principal objective is to determine the ability of the VRI to assess changes in the lungs before and after pulmonary intervention in patients suffering from airway obstruction. | Baseline and follow-up up to 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| The secondary objective is to assess the contribution of the VRI in aiding in identification of the pulmonary obstruction as compared to the standard methods prior the intervention procedure. | Baseline |
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Inclusion Criteria:
Exclusion Criteria:
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Patients in the age range of 18-85 and consisting of both male and females, who present to the clinic with airway obstruction and who are designated to undergo intervention.
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| Name | Affiliation | Role |
|---|---|---|
| Heinrich D Becker, M.D. | Thoraxklinik at Heidelberg University School of Medicine | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| National Jewish Medical and Research Center | Denver | Colorado | 80602 | United States | ||
| Duke University Medical Center |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 17551264 | Background | Dellinger RP, Parrillo JE, Kushnir A, Rossi M, Kushnir I. Dynamic visualization of lung sounds with a vibration response device: a case series. Respiration. 2008;75(1):60-72. doi: 10.1159/000103558. Epub 2007 Jun 4. | |
| 15187010 | Background | Ernst A, Feller-Kopman D, Becker HD, Mehta AC. Central airway obstruction. Am J Respir Crit Care Med. 2004 Jun 15;169(12):1278-97. doi: 10.1164/rccm.200210-1181SO. |
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| ID | Term |
|---|---|
| D012135 | Respiratory Sounds |
| D000402 | Airway Obstruction |
| ID | Term |
|---|---|
| D012818 | Signs and Symptoms, Respiratory |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012131 | Respiratory Insufficiency |
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| Durham |
| North Carolina |
| 27710 |
| United States |
| Hospital St. Marguerite | Marseille | 13274 | France |
| Thoraxklinik at Heidelberg University | Heidelberg | D-69126 | Germany |
| St. Marianna Hospital | Kawasaki | Kanagawa | 216-8511 | Japan |
| D012120 | Respiration Disorders |
| D012140 | Respiratory Tract Diseases |