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Purpose:Evaluate the feasibility of T2 cartilage mapping on MRI of the wrist and correlate with T2 mapping of knee cartilage.
Study protocol: Phase 1. 10 healthy volunteers, Phase 2. 10 volunteers with osteoarthritis of the wrist, Phase 3. 50 patients for studies for routine MR of the wrist.
MRI protocol: 3 T unit((Signa EXITE HDx),T1, T2 and T2 mapping sequences on axial and coronal orientation.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1 | healthy young volunteers Inclusion: age 18-40, Exclusion: wrist trauma/surgery | ||
| 2 | patients with know osteoarthritis wrist changes according to pre-existing x-rays No age limits exclusion: previous wrist surgery | ||
| 3 | Mixed group of 50 patients that perform routine MRI of the wrist for various indications |
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| Measure | Description | Time Frame |
|---|---|---|
| wrist bone cartilage thickness can be measured and stratification can be observed on T2 mapping with correlation to T2 mapping of the knee cartilage | Within MRI completion (20 minutes) |
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Inclusion Criteria:
Exclusion Criteria:
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healthy volunteers, volunteers with known osteoarthritis, routine MR population for wrist investigation
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| Name | Affiliation | Role |
|---|---|---|
| Iris Eshed, MD | Sheba Medical Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Sheba Medical Center , Diagnostic Imaging Dept | Recruiting | Tel Litwinsky | Tel Hashomer | 52621 | Israel |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 15893528 | Background | Glaser C. New techniques for cartilage imaging: T2 relaxation time and diffusion-weighted MR imaging. Radiol Clin North Am. 2005 Jul;43(4):641-53, vii. doi: 10.1016/j.rcl.2005.02.007. | |
| 16177408 | Background | Recht MP, Goodwin DW, Winalski CS, White LM. MRI of articular cartilage: revisiting current status and future directions. AJR Am J Roentgenol. 2005 Oct;185(4):899-914. doi: 10.2214/AJR.05.0099. |
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| ID | Term |
|---|---|
| D010003 | Osteoarthritis |
| ID | Term |
|---|---|
| D001168 | Arthritis |
| D007592 | Joint Diseases |
| D009140 | Musculoskeletal Diseases |
| D012216 | Rheumatic Diseases |
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| Sheba Medical Center, Diagnostic Imaging Dept | Enrolling by invitation | Tel Litwinsky | Tel Hashomer | 52621 | Israel |
| 10644134 | Background | Mosher TJ, Dardzinski BJ, Smith MB. Human articular cartilage: influence of aging and early symptomatic degeneration on the spatial variation of T2--preliminary findings at 3 T. Radiology. 2000 Jan;214(1):259-66. doi: 10.1148/radiology.214.1.r00ja15259. |