High-Field MRI Characterization of Wrist and Hand Cartilage Abnormalities in Inflammatory and Chronic Rheumatisms

High-Field MRI Characterization of Wrist and Hand Cartilage Abnormalities in Inflammatory and Chronic Rheumatisms

The present project aims at evaluating the diagnostic potential of high-field MRI (3 Teslas) for joint disease. At this field, given that isotropic image resolution of 400 microns can be obtained, one could expect an early detection of joint abnormalities. The additional aim of this project will be to develop a quantitative analyse of the corresponding high-resolution images.

Inclusion Criteria:

• gp Suspects or affected by rheumatoid polyarthritis

  1. Morning articular Stiffness of at least 15 minutes.
  2. Arthalgias or Arthritises of at least three joints(articulations), among which those of the hand.
  3. Possible rheumatoid Presence of a factor(mailman) and\or Antibody anti peptides positive citrullinés.
  4. Typical possible radiological Hurts on the standard clichés(pictures) of the reached(affected) joints(articulations).

• gp Affected by stiffening spondylitis with axial and peripheral infringement :

  . Lumbago and steepness lumbar vertebra inflammatory. 2. Arthralgias and\or peripheral arthritises 3. Possible presence of an allèle HLA 4. Possible presence of a sacro-illite 5. Absence of the other rheumatic markers

• gp Affected by connectivity with anti-nuclear antibody positive and / or specific antibodies, suffering of polyarthralgias with or without arthritis

• gp Healthy control

• gp Presenting a degenerative osteoarthritis of the wrist traumatic comment, noticed radiologically, which will serve as not inflammatory control.

Exclusion Criteria:

• Claustrophobia,
• metallic foreign bodies,
• pacemakers The pregnant women,
• parturients or who breast-feed are excluded from the study