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Hip osteoarthritis is a frequent and invalidating disease. Early detection of cartilage modifications could provide better patient treatment. The T1rho MRI sequence allows the quantification of the cartilage signal that is correlated to modifications of the cartilage matrix, notably of the proteoglycans. The primary objective is to evaluate normal values of hip cartilage in vivo using T1rho MRI in healthy subjects and the reproducibility of the measurements. T1rho and T2 mapping sequences were acquired twice during the same session with 30 minutes interval to see if values were modified after a 30 minutes delay in a supine position. The secondary objective was to assess the correlation between T1rho and T2 values.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| T1rho MRI | Experimental | Patients included had hip cartilage MRI with acquisition of T1rho MRI sequence. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Hip cartilage MRI | Device | Hip cartilage MRI |
|
| Measure | Description | Time Frame |
|---|---|---|
| Quantification of the cartilage signal at T1rho MRI | T1rho values of total hip cartilage and for each sub-region (mean, standard deviation, histogram) | Up to one month after inclusion (Visit 1) |
| Measure | Description | Time Frame |
|---|---|---|
| Quantification of the cartilage signal at T1rho MRI | T1rho values of total hip cartilage and for each sub-region (mean, standard deviation, histogram) | 15 (+/- 7) days after visit 1 (Visit 2) |
| Quantification of the cartilage signal at T2 MRI |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Jean-Baptiste PIALAT, MD, PhD | Hospices Civils de Lyon | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hospices Civils de Lyon - Hôpital Edouard Herriot Pavillon B Radiologie | Lyon | 69437 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 28650110 | Result | Nemeth A, Di Marco L, Boutitie F, Sdika M, Grenier D, Rabilloud M, Beuf O, Pialat JB. Reproducibility of in vivo magnetic resonance imaging T1 rho and T2 relaxation time measurements of hip cartilage at 3.0T in healthy volunteers. J Magn Reson Imaging. 2018 Apr;47(4):1022-1033. doi: 10.1002/jmri.25799. Epub 2017 Jun 26. |
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T2 values of total hip cartilage and for each sub-region (mean, standard deviation, histogram)
| Up to one month after inclusion (Visit 1) |
| Quantification of the cartilage signal at T2 MRI | T2 values of total hip cartilage and for each sub-region (mean, standard deviation, histogram) | 15 (+/- 7) days after visit 1 (Visit 2) |
| Presence of cartilage lesions | Morphological sequence to determine focal lesions | Up to one month after inclusion (Visit 1) |
| Presence of cartilage lesions | Morphological sequence to determine focal lesions | 15 (+/- 7) days after visit 1 (Visit 2) |