This study will evaluate the effectiveness and tolerability of MK8141 in lowering blood pressure in patients who have hypertension (high blood pressure).

Inclusion Criteria:

• You are 35 to 65 years of age
• In the past 14 days you have not been treated for hypertension
• In the past 14 days you have not taken more than 2 medications to treat high blood pressure
• You are a woman who is not able to have children or do not use birth control

Exclusion Criteria:

• You are taking more than 2 medications to treat high blood pressure
• You have a history of a stroke, transient ischemic attack (TIA), heart attack, congestive heart failure, coronary artery bypass surgery
• You have Type 1 or 2 diabetes mellitus
• You have an active liver disease, gallbladder disease, or bowel disease
• You are HIV positive
• You have certain types of cancer
• You abuse drug or alcohol
• You have participated in another clinical study in last 4 weeks