MK0954 Versus Placebo for Treatment of Mild to Moderate Hypertension

A Double-Blind, Randomized, Parallel, Placebo-Controlled Study to Investigate the Antihypertensive Efficacy and Safety of Losartan Given Once or Twice Daily in Patients With Mild to Moderate Hypertension

The study had a 4 week single blind placebo period followed by 12 weeks of double blind treatment. Patients were randomized to one of four treatment arms to evaluate the antihypertensive efficacy of Losartan.

Inclusion Criteria:

• Patient has been diagnosed with mild to moderate hypertension
• Patient has no treatment or active medical problem, other than hypertension that might affect the patients blood pressure

Exclusion Criteria:

• Pregnant of lactating female patients
• Secondary hypertension or history of malignant hypertension
• Sitting systolic blood pressure > 210 mmHg
• History of stroke
• History of myocardial infarction with in the past year
• Current of prior history of heart failure
• Known hypersensitivity to losartan
• Obesity
• Patients known to be HIV positive or known to be positive for Hepatitis B
• Absence of one kidney
• Patient is abusing or previously abused alcohol or drugs with in past two years