A Study to Investigate the Antihypertensive Efficacy of MK0954

A Multicenter, Double-Blind, Randomized, Placebo-Controlled Clinical Study to Evaluate the Antihypertensive Efficacy and Safety of Losartan (MK954, DuP753) in Patients With Mild to

After a 4 week placebo period, patients were randomized to Placebo or Losartan 50 mg arms, after 6 weeks non-responders were up titrated to 100 mg losartan for the remaining 6 weeks. This study evaluated if losartan is more effective than placebo in lowering sitting diastolic blood pressure and is well tolerated in patients with mild to moderate hypertension.

Inclusion Criteria:

• Patient has been diagnosed with mild to moderate hypertension (SDBP 95-115 mm Hg)
• Patient has no medical problems or treatments that might effect their blood pressure

Exclusion Criteria:

• Pregnant or lactating females
• Patient has secondary hypertension or malignant hypertension
• Sitting systolic blood pressure > 210 mm Hg
• History of stroke
• History of myocardial infarction with in past year
• Current or prior history of heart failure
• Known hypersensitivity to losartan
• Prior exposure to losartan
• Patients known to be HIV positive
• Patient is abusing or has abused alcohol or other drugs within the past 4 years