A Study to Investigate the Magnitude and Duration of Response of MK0954 Compared to Placebo in Patients With Hypertension (0954-021)(COMPLETED)

A Double-blind, Randomized, Parallel-group, Placebo-controlled Pilot Study to Investigate the Magnitude and Duration of Response and the Safety of MK0954 (50 mg Given Once or Twice Daily, or 100 mg Given Once Daily) Compared to Placebo Using Ambulatory Blood Pressure Monitoring

The purpose of this study was to evaluate the magnitude and durations of the antihypertensive effects of losartan using ambulatory blood pressure monitoring (ABPM), and to evaluate the safety of losartan 50 and 100 mg doses compared to placebo.

Inclusion Criteria:

• Non-black men and women with mild to moderate hypertension and within 30% of their ideal body weight
• Patient is in good general health
• Blood pressure at time of randomization is 95-115 mm Hg

Exclusion Criteria:

• Secondary Hypertension or history of malignant hypertension
• History of stroke
• History of myocardial infarction
• Atrial flutter or atrial fibrillation
• History of congestive Heart failure
• Patient taking major psychotropic agent or anti-depressant
• Patient regularly uses NSAIDS or high dose aspirin
• Known positive test for HIV/AIDS or Hepatitis B
• Patient is being treated for acute ulcer disease
• Prior exposure to losartan
• Actively treated diabetes mellitus
• History of chronic liver disease
• Actively treated diabetes mellitus
• Any known bleeding or platelet disorder
• Absence of one kidney
• Women of childbearing potential
• Alcoholism or drug addiction