The Effect of High and Low Sodium Intake on Urinary Aquaporin-2 in Healthy Humans.

The Effect of High and Low Sodium Intake on Aquaporin-2 in Healthy Humans, During Basal Conditions and After Hypertonic Saline Infusion.

The aim of the study is to test the hypothesis that the function and/or regulation of aquaporin 2 and/or endothelial sodium channels in the principal cells of healthy humans is abnormal at high and low sodium intake

Inclusion Criteria:

• Caucasic men and women
• Age 18-65 years
• Body mass index less or equal to 30 Kg/m2

Exclusion Criteria:

• Arterial hypertension
• History or clinical signs of heart, brain, lung, kidney, malignant or endocrine organ disease.
• Abnormal biochemical screening of the blood regarding: red and white cell count, B-hemoglobin, P-sodium, P-potassium, P-creatinine, P-albumine, P- bilirubin, P-alanine aminotransferase, P- alkaline phosphatase, p-cholesterol and B-glucose.
• Abnormal screening of the urine regarding: blood, albumine and glucose.
• Alcohol or drug abuse
• Drug use except oral contraceptives
• Smoking
• Abnormal electrocardiogram
• Blood donation within one month of the first examination day
• Pregnancy
• Unwillingness to participate