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The aim of the study is to test the hypothesis that the function and/or regulation of aquaporin 2 and/or endothelial sodium channels in the principal cells of healthy humans is abnormal at high and low sodium intake
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| High Sodium Diet | Behavioral | 250-350 mmol | ||
| Low Sodium Diet | Behavioral | 25-35 mmol |
| Measure | Description | Time Frame |
|---|---|---|
| u-AQP-2 | Before and after hypertonic saline infusion after 4 days on high and low sodium diet, respectively. | |
| fractional sodium excretion | Before and after hypertonic saline infusion after 4 days on high and low sodium diet, respectively. | |
| p-aldosterone | Before and after hypertonic saline infusion after 4 days on high and low sodium diet, respectively. |
| Measure | Description | Time Frame |
|---|---|---|
| u-pAQP-2 | Before and after hypertonic saline infusion after 4 days on high and low sodium diet, respectively. | |
| u-ENaC(alfa-beta-gamma) | Before and after hypertonic saline infusion after 4 days on high and low sodium diet, respectively. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Erling B. Pedersen, Professor | Department of Medical Research, Holstebro Hospital, Denmark | Study Chair |
| Carolina C. Graffe, MD | Department of Medical Research, Holstebro Hospital, Denmark | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Medical Research, Holstebro Hospital | Holstebro | Holstebro | 7500 | Denmark |
| Type | Date | Date Unknown |
|---|---|---|
| Release | Oct 25, 2012 | |
| Reset | Nov 23, 2012 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Oct 25, 2012 | Nov 23, 2012 |
| ID | Term |
|---|---|
| D004039 | Diet, Sodium-Restricted |
| ID | Term |
|---|---|
| D004035 | Diet Therapy |
| D044623 | Nutrition Therapy |
| D013812 | Therapeutics |
| D004032 | Diet |
| D009747 |
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| CH20 | Before and after hypertonic saline infusion after 4 days on high and low sodium diet, respectively. |
| ucAMP | Before and after hypertonic saline infusion after 4 days on high and low sodium diet, respectively. |
| uPGE2 | Before and after hypertonic saline infusion after 4 days on high and low sodium diet, respectively. |
| GFR | Before and after hypertonic saline infusion after 4 days on high and low sodium diet, respectively. |
| Nutritional Physiological Phenomena |
| D000066888 | Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |