Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The aim of the study is to test the following hypotheses:
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| high sodium diet | Behavioral | 250-350 mmol |
| |
| Low Sodium Diet | Behavioral | 25-35 mmol |
|
| Measure | Description | Time Frame |
|---|---|---|
| u-AQP-2 | Before and after hypertonic saline infusion after 4 days on high and low sodium diet, respectively. | |
| fractional sodium excretion | Before and after hypertonic saline infusion after 4 days on high and low sodium diet, respectively. | |
| p-vasopressin | Before and after hypertonic saline infusion after 4 days on high and low sodium diet, respectively. | |
| p-aldosterone | Before and after hypertonic saline infusion after 4 days on high and low sodium diet, respectively. |
| Measure | Description | Time Frame |
|---|---|---|
| u-p-AQP-2 | Before and after hypertonic saline infusion after 4 days on high and low sodium diet, respectively. | |
| u-ENaC(alfa,beta,gamma) | Before and after hypertonic saline infusion after 4 days on high and low sodium diet, respectively. |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Erling B. Pedersen, Professor | Department of Medical Research, Holstebro Hospital, Denmark | Study Chair |
| Carolina C. Graffe, MD | Department of Medical Research, Holstebro Hospital, Denmark | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Medical Research, Holstebro Hospital | Holstebro | 7500 | Denmark |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 22452789 | Derived | Graffe CC, Bech JN, Lauridsen TG, Vase H, Pedersen EB. Abnormal increase in urinary aquaporin-2 excretion in response to hypertonic saline in essential hypertension. BMC Nephrol. 2012 Mar 27;13:15. doi: 10.1186/1471-2369-13-15. |
Not provided
Not provided
| Type | Date | Date Unknown |
|---|---|---|
| Release | Nov 1, 2012 | |
| Reset | Nov 30, 2012 |
Not provided
Not provided
| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Nov 1, 2012 | Nov 30, 2012 |
| ID | Term |
|---|---|
| D000075222 | Essential Hypertension |
| ID | Term |
|---|---|
| D006973 | Hypertension |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
Not provided
Not provided
| ID | Term |
|---|---|
| D004039 | Diet, Sodium-Restricted |
| ID | Term |
|---|---|
| D004035 | Diet Therapy |
| D044623 | Nutrition Therapy |
| D013812 | Therapeutics |
| D004032 | Diet |
| D009747 |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| CH2O | Before and after hypertonic saline infusion after 4 days on high and low sodium diet, respectively. |
| u-cAMP | Before and after hypertonic saline infusion after 4 days on high and low sodium diet, respectively. |
| uPGE2 | Before and after hypertonic saline infusion after 4 days on high and low sodium diet, respectively. |
| GFR | Before and after hypertonic saline infusion after 4 days on high and low sodium diet, respectively. |
| Nutritional Physiological Phenomena |
| D000066888 | Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |