Urinary Aquaporin 2 Excretion After NSAID in Fasting Healthy Human

Urinary Aquaporin 2 Excretion After NSAID in Fasting Healthy Human

We wanted to test the hypothesis that prostaglandin inhibition reduces the down regulation of u-AQP-2 induced by fasting

Inclusion Criteria:

• (1) Genders; both mal and female
• (2) Age; 18- 65 years old
• (3) BMI; below 30
• (4) Females had to bee in oral contraceptive treatment

Exclusion Criteria:

• (1) Clinical signs or history of disease in the heart, lungs, kidneys or endocrine organs
• (2) Abnormal laboratory test (blood haemoglobin, white cell count, platelets, plasma sodium, plasma potassium, plasma creatinine, plasma albumin, plasma bilirubin, plasma alanine aminotransferase, plasma cholesterol and blood glucose)
• (3) Albuminuria or glucosuria
• (4) Cancer
• (5) Arterial hypertension
• (6) Alcohol abuse
• (7) Use of tobacco
• (8) Medical treatment, except oral contraceptives
• (9) Pregnancy or breast feeding
• (10) Medicine abuse
• (11) Donation of blood less than 1 month before the study.