Attention-based Binocular Training for Impaired Stereopsis (BRAVE)

ClinicalTrials.gov ID

NCT07803458

Lead Sponsor

Centre for Eye and Vision ResearchOTHER

Overall Status

Not yet recruiting

Study Type

Interventional

Phase

Not Applicable

Enrollment

56Estimated

Last Update Posted

Sep 3, 2026Actual

Start Date

Nov 1, 2026Estimated

Primary Completion Date

Dec 31, 2028Estimated

Completion Date

Mar 30, 2029Estimated

Official Title

Binocular Recovery Through Attention-based Visual Enhancement: A Randomized Controlled Trial (BRAVE Trial)

Brief Summary

This study evaluates a novel attention-based binocular visual search training paradigm designed to improve stereopsis (stereo vision) in individuals with impaired binocular vision. Disruptions in balanced binocular input, such as from strabismus or anisometropia, often lead to deficient stereo vision, causing daily visuomotor limitations. While traditional therapies focus on monocular acuity, they frequently fail to restore stereopsis, especially in adults. The investigators propose a unique dichoptic visual search training method that embeds binocular disparity inside an attention-demanding task, encouraging cooperative binocular integration. Participants aged 18-39 with impaired stereopsis will be randomly assigned in a 1:1 ratio to either the active training group (disparity-embeded task) or the active control group (identical task with zero disparity). Both groups complete 5 training sessions over 5-6 weeks. Assessments will occur at baseline, immediately post-training, and at a 12-week follow-up. The primary objective is to determine if the active training group shows significantly greater improvements in local stereoacuity compared to the control group.

• Amblyopia
• Strabismus
• Anisometropia
• Binocular Vision Abnormalities
• Binocular Vision Disorder

• Attention-Guided Dichoptic Visual Search Training
• Zero-Disparity Dichoptic Visual Search Task

Ages Eligible for Study

Adult (18-64)

Sexes Eligible for Study

All

Accepts Healthy Volunteers

Yes

Eligibility Criteria

Inclusion Criteria:

• Aged 18-39 years (inclusive).
• Deficient or anomalous stereoscopic vision with a stereoacuity >= 70 sec arc or unmeasurable stereoacuity.
• Best corrected visual acuity (BCVA) of < 0.80 logMAR in both eyes, with at least one eye having a visual acuity of <= 0.1 logMAR (uncorrected or corrected-to-normal with glasses or contact lenses).
• Normal colour vision.
• Good general health.

Exclusion Criteria:

• Previous history of ocular surgery (except for refractive correction surgery, where appropriate).
• Pre-existing ocular conditions or medications that affect vision or visual function.
• Pre-existing conditions or medications that affect neuropsychological function.
• Presence of strabismus over 10 prism diopters at distance in current refractive correction measured by simultaneous prism and cover test, or large eccentric fixation.
• Previous history of experiencing double vision (diplopia).
• Identified at risk of developing diplopia due to binocular state and/or poor binocular control.
• Inability to comprehend psychophysical test instructions given and/or consent for themselves.

Primary Purpose

Treatment

Allocation

Randomized

Interventional Model

Parallel Assignment

Masking

Single

Lead Sponsor

Centre for Eye and Vision ResearchOTHER

Collaborators

The Hong Kong Polytechnic UniversityOTHER

University of WaterlooOTHER

jeffrey.tw.leung@polyu.edu.hk+852-64080394

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