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| ID | Type | Description | Link |
|---|---|---|---|
| 26CDA1590827 | Other Grant/Funding Number | American Heart Association |
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| Name | Class |
|---|---|
| American Heart Association | OTHER |
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The BRIGHT (Behavioral Rehabilitation Through Image-Guided Home-based Training) study aims to evaluate the effectiveness of image-guided, home-based perceptual training at improving visual performance in individuals with visual field loss.
Using a prospective, crossover design, BRIGHT combines visual behavioral testing, neuroimaging, and a home-based intervention. It aims to 1) identify neural pathways that support training-induced visual plasticity; and 2) compare the efficacy of different types of visual training delivered in a home-based setting.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Perceptual learning-based training using high-level visual stimuli | Experimental | A 3 week at-home online perceptual learning-based training using high-level visual stimuli. |
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| Perceptual learning-based training using low-level visual stimuli | Active Comparator | A 3 week at-home online perceptual learning-based training using low-level visual stimuli. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| High-level perceptual learning-based training | Behavioral | Behavioral intervention consisting of repeated computerized visual discrimination tasks targeting higher-order visual processing |
| Measure | Description | Time Frame |
|---|---|---|
| Change in high-level perceptual discrimination performance | Change in performance on an online computerized high-level perceptual discrimination task. Participants complete a computerized high-level perceptual discrimination task during a 3-week training period (5 days per week). Task difficulty is adaptively adjusted using a 3-up/1-down staircase procedure to estimate perceptual discrimination thresholds corresponding to approximately 75% accuracy. | Week 2-4 or Week 7-9 of the study (depending on the order) |
| Change in low-level perceptual discrimination performance | Change in performance on an online computerized low-level perceptual discrimination task. Participants complete a computerized high-level perceptual discrimination task during a 3-week training period (5 days per week). Task difficulty is adaptively adjusted using a 3-up/1-down staircase procedure to estimate perceptual discrimination thresholds corresponding to approximately 75% accuracy. | Week 2-4 or Week 7-9 of the study (depending on the order) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Tina Liu, PhD | Contact | 2027849920 | tina.liu@georgetown.edu |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Georgetown University Medical Center | Recruiting | Washington D.C. | District of Columbia | 20057 | United States |
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Study Procedures
Week 1: Pre-intervention visual assessment and functional magnetic resonance imaging (fMRI) scan (in-person study visit).
Weeks 2-4: Participants complete at-home, online perceptual learning training using either low-level or high-level visual stimuli.
End of Week 4: Online assessment to evaluate the spatial transfer of training effects.
Weeks 5-6: Washout period to minimize potential carryover effects.
Weeks 7-9: Participants complete the alternate at-home, online perceptual learning training condition (low-level or high-level visual stimuli).
End of Week 9: Second online assessment to evaluate the spatial transfer of training effects.
Week 10 (Final Visit): Post-intervention visual assessment and fMRI scan (in-person study visit).
Approximately Week 24: Follow-up visual assessment and fMRI scan (in-person study visit).
The timing of study visits and training sessions may be adjusted as needed to accommodate participants' health status, scheduling needs, or o
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| Low-level perceptual learning-based training | Behavioral | behavioral intervention consisting of repeated computerized visual discrimination tasks targeting low-level visual processing |
|
| ID | Term |
|---|---|
| D020521 | Stroke |
| D006423 | Hemianopsia |
| D019575 | Blindness, Cortical |
| D000070642 | Brain Injuries, Traumatic |
| D001932 | Brain Neoplasms |
| ID | Term |
|---|---|
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D014786 | Vision Disorders |
| D012678 | Sensation Disorders |
| D009461 | Neurologic Manifestations |
| D001766 | Blindness |
| D005128 | Eye Diseases |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D001930 | Brain Injuries |
| D006259 | Craniocerebral Trauma |
| D020196 | Trauma, Nervous System |
| D014947 | Wounds and Injuries |
| D016543 | Central Nervous System Neoplasms |
| D009423 | Nervous System Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
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