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The VIBRANT (Vision Improvement through Behavioral Rehabilitation And Neuroplasticity Training) study is a prospective, double-blind, crossover design (within-subject) in participants with homonymous hemianopia-a type of visual field loss resulting from damage to the post-chiasmatic visual pathways. It aims to investigate whether transcranial random noise stimulation (tRNS) combined with perceptual learning-based training has potential for improving visual impairments.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| tRNS with perceptual learning-based training | Experimental | Each 2-day session consists of up to three 18-minute transcranial random noise stimulation (tRNS) paired with perceptual learning-based training. |
|
| Sham with perceptual learning-based training | Sham Comparator | Each 2-day session consists of up to three 18-minute sham stimulation paired with perceptual learning-based training. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| transcranial random noise stimulation (tRNS) | Device | Stimulation location: bilateral human middle temporal complex (hMT+). Stimulation parameters: 1 mA current intensity, with a frequency range of 101-640 Hz. |
| Measure | Description | Time Frame |
|---|---|---|
| Change in Motion Discrimination Performance | Change in accuracy on a computerized motion direction discrimination task programmed in the lab. The task assesses participants' ability to discriminate the direction of the peripherally presented moving dots at two locations (one within the blind field and the other at a mirror-symmetric location in the intact visual field). Accuracy is defined as the proportion of correct responses out of the total number of trials completed. | Study visit 1 to 2 (within a week), and study visit 3 to 4 (within a week) |
| Measure | Description | Time Frame |
|---|---|---|
| Visual Field Change | Change in visual field function, assessed by perimetric mean deviation (PMD) measured using Humphrey perimetry. PMD is a global index representing the average deviation of visual field sensitivity compared to age-matched norms, measured in decibels (dB). More negative PMD values indicate greater visual field loss. | Baseline (pre-intervention) to post-intervention follow-up (approximately 3 months, up to 6 months) |
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A. Stroke, brain tumor, or traumatic brain injury patients
Inclusion Criteria:
Exclusion Criteria:
B. Healthy volunteers (age-matched controls):
Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Tina Liu, PhD | Contact | 2027849920 | tina.liu@georgetown.edu | |
| Kyungji Moon, MS | Contact | 2027849949 | vpplab@georgetown.edu |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Georgetown University Medical Center | Recruiting | Washington D.C. | District of Columbia | 20057 | United States |
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| ID | Term |
|---|---|
| D020521 | Stroke |
| D006423 | Hemianopsia |
| D019575 | Blindness, Cortical |
| D001932 | Brain Neoplasms |
| D000070642 | Brain Injuries, Traumatic |
| ID | Term |
|---|---|
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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| ID | Term |
|---|---|
| D065908 | Transcranial Direct Current Stimulation |
| ID | Term |
|---|---|
| D004599 | Electric Stimulation Therapy |
| D013812 | Therapeutics |
| D003295 | Convulsive Therapy |
| D013000 | Psychiatric Somatic Therapies |
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This study is double-blind, meaning that both the participants and the researchers will be blinded to the treatment conditions.
| Sham Stimulation | Device | Stimulation location: bilateral human middle temporal complex (hMT+). Stimulation parameters: Ramp up stimulation at 1mA with a frequency range of 101-640Hz for the first 30 seconds followed by no current for the remainder of the duration. |
|
| Perceptual learning-based training | Behavioral | A motion discrimination task, judging the global direction of moving dot stimuli with two different coherence levels. |
|
| Visual Perception Change | Change in visual perception in the following two task:
Performance on both tasks will be measured at visual field locations targeted by brain stimulation and at control visual field locations not targeted by brain stimulation. | Baseline (pre-intervention) to post-intervention follow-up (approximately 3 months, up to 6 months) |
| Quality of Life Change | Change in quality of life evaluated using the National Eye Institute 25 Item Visual Function Questionnaire (NEI-VFQ 25). Scores range from 0 to 100, with higher scores indicating better vision-related quality of life. | Baseline (pre-intervention) to post-intervention follow-up (approximately 3 months, up to 6 months) |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D014786 | Vision Disorders |
| D012678 | Sensation Disorders |
| D009461 | Neurologic Manifestations |
| D001766 | Blindness |
| D005128 | Eye Diseases |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D016543 | Central Nervous System Neoplasms |
| D009423 | Nervous System Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D001930 | Brain Injuries |
| D006259 | Craniocerebral Trauma |
| D020196 | Trauma, Nervous System |
| D014947 | Wounds and Injuries |
| D004191 | Behavioral Disciplines and Activities |
| D004597 | Electroshock |
| D011580 | Psychological Techniques |