The Effect of Aerobic Exercise on the Irisin/Klotho/Sirtuin-1/BDNF Axis

The Effect of Aerobic Exercise on the Irisin/Klotho/Sirtuin-1/BDNF Axis: A Randomized Controlled Study

The purpose of this study is to investigate the effects of an acute aerobic exercise on irisin, klotho, sirtuin-1, and BDNF levels in the healthy adults. The findings will help understand the physiological impacts of exercise on these biomarkers.

Inclusion Criteria:

• Being between the ages of 18 and 45
• Being in good health and having no diagnosis of any chronic disease
• Not having taken regular medication within the last 4 weeks
• Voluntary participation and providing written informed consent

Exclusion Criteria:

• Individuals with a history of cardiovascular, endocrine, metabolic, or renal disease
• Individuals with a history of active infection, musculoskeletal injury, or severe disability
• Individuals with any medical condition that might prevent participation in exercise
• Individuals unable to regularly participate in the exercise protocol throughout the study