Background: RA may progress with articular and non-articular involvement.Depression prevelance is found to increase for RA patients according to healthy population and to be correlated with pain, decreased quality of life, fatigue and physical disability.BDNF level was found significantly lower in RA patients with depression. Aim of this study is to investigate the variation of BDNF, VEGF, TNF- α, IL-6, IL-1β, irisin and α- Klotho levels following acute exercise.

Methods: This study included 45 RA patients and 45 age and sex matched healthy controls. Blood samples from all subjects were taken and centrifuged before and immediately after the exercise intervention.

Inclusion Criteria:

• Patients who were aged between 18-65 years,
• Patients who got diagnosed according to American College of Rheumatology criteria
• Patients who were being followed at Firat University Department of Rheumatology

Exclusion Criteria:

• Patients who had regular exercise habits, malignancy, pregnancy, incorporation,
• Patients who took anti-TNF treatment
• Patients who had changes of medical treatment in last 3 months
• Patients who diagnosed with Fibromyalgia Syndrome and Osteoarthritis for lower extremity
• Patients who had cardiac symptoms according to New York Heart Association
• Patients who had dysfunction that can prevent physical activity