Speed of Processing Training to Improve Cognitive Functioning and Driving Performance in Head and Neck Cancer Survivors | NCT07740616

NCT07740616

Overview

NCT ID: NCT07740616
Lead Sponsor: University of Alabama at BirminghamOTHER
Official Title: Speed of Processing Training to Improve Cognitive Functioning and Driving Performance in Head and Neck Cancer Survivors
Brief Summary: The goal of the study is to understand how well cognitive training improves reaction time in people with head and neck cancer (HNC). Aim 1. Evaluate the preliminary clinical effectiveness of a 10-week home- and video game-based SOPT on cognitive functioning and driving performance in HNC survivors. This study will include completing five questionnaires and simulated driving in a simulator at two different times, 10 weeks of participating in 2 sessions per week of video-game cognitive training at home and being interviewed once at the end of the 10-week training.
Conditions: Head and Neck Cancer (H&N)

Status and Timeline

Status: Not yet recruiting
Last Update Posted: Jul 31, 2026Actual
Start Date: Sep 3, 2026Estimated
Primary Completion Date: Sep 2028Estimated
Completion Date

Participation Criteria

Ages Eligible for Study: Adult (18-64)Older Adult (65+)
Sexes Eligible for Study: All
Accepts Healthy Volunteers?: No
Eligibility Criteria: Inclusion Criteria:

confirmed HNC diagnosis

aged ≥ 18 years of all racial, ethnic, and sex/gender categories

≥ 6 months post radiation or chemoradiation

self-reported CRCI, defined as a score of ≥ 60 in the FACT-Cog Perceived Cognitive Impairment subscale

thyroid-stimulating hormone levels within normal limits

visual acuity of at least 20/40 using a Snellen eye chart

functional peripheral vision as indicated by the confrontation field test

functional hearing sufficient to engage in daily conversation in English for ≥ 15 minutes

intact lower extremity function (Rapid Pace Walk test ≤ 9 sec)

stable home internet

sufficient English proficiency to read and understand informed consent materials

Exclusion Criteria:

significant neurologic or psychiatric comorbidities, including psychotic disorders, bipolar disorders, Alzheimer's disease or related dementias, developmental disorders, seizure disorders, vestibular disorders, prior brain tumor or brain surgery, or poorly controlled metabolic disease

current use of antipsychotic or mood-stabilizing medications due to potential effects on driving performance

anticipated life expectancy of < 6 months based on physician prognosis.

Study Plan

Study Type: Interventional
Phase: Not Applicable
Enrollment: 30Estimated
Primary Purpose: Other
Allocation: Randomized
Interventional Model: Parallel Assignment
Masking: Single

Contacts and Locations

Central Contacts: Hon YuenContact
yuen@uab.edu12059346301

Similar Studies

Participant Group/Arms

Speed of Processing TrainingExperimental

The training is the game-based cognitive exercises that involve the speed and accuracy of visual information processing and enhance divided attention between central and peripheral stimuli and among peripheral stimuli when distractors are present.

Other: Speed of Processing Training

Home-Based Sham TrainingSham Comparator

The sham condition includes five interactive video game activities that are self-paced, non-adaptive, and not designed to affect processing speed.

Other: Home-Based Sham Training