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| Name | Class |
|---|---|
| Unity Health Toronto | OTHER |
| Sunnybrook Health Sciences Centre | OTHER |
| Lakehead University | OTHER |
| McGill University |
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The objective of this study is to assess the effectiveness of an intervention to address both executive function and processing speed changes that contribute to poor driving performance in adults with Mild Cognitive Impairment (MCI).
Our hypotheses are that the study intervention will improve performance on a driving simulator and will improve (i) executive function, specifically attention and planning, (ii) useful field of view, (iii) mood, (iv) quality of life, and (v) reported motor vehicle crashes and driving infractions.
Executive function and processing speed are recognized critical correlates of driving performance and have been shown to decline in older adults and in persons with mild cognitive impairment. Members of our research team have shown that group executive function training such as Goal Management Training results in benefits for healthy older adults, including improved simulated daily activities. The ultimate purpose of our research is to develop interventions to help maintain older adults' mobility in order to assist their 'aging at home'. The planned study will assess the effectiveness of an intervention that includes Goal Management Training + processing speed training (using DriveSharp software), which is designed to address both executive function and processing speed changes that contribute to poor driving performance in people with diagnosed mild cognitive impairment. The investigators will measure the effectiveness of the intervention on driving performance, sustained attention, divided attention, executive function, depressive symptoms and quality of life.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Goal Management Training + Processing Speed Training | Experimental | Group receives both Goal Management Training and as well as Processing Speed Training using DriveSharp software. |
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| Processing Speed Training + Brain Health Workshop | Active Comparator | Group receives both Processing Speed Training (using DriveSharp) and participates in a Brain Health Workshop that is matched to Goal Management Training for session length and contact with trainer. |
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| Brain Health Workshop + computer assignments | Placebo Comparator | Group participates in Brain Health Workshop and is provided with computer assignments to match for time spent on the computer in the other arms. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Goal Management Training | Behavioral | 9 weeks, 2 hour session/week, 1 hour/day homework (6 days/week), 2 x 0.5 hour sessions with trainer |
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| Measure | Description | Time Frame |
|---|---|---|
| Driving Performance | Measurements obtained on a computer-based driving simulation | 9-14 weeks |
| Driving Performance | Measurements obtained on a computer-based driving simulation | 33-38 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Sustained Attention to Response Task (SART) | Sustained attention | 9-14 weeks, 33-38 weeks |
| D-KEFs Tower Test | Visuospatial planning | 9-14 weeks, 33-38 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Gary Naglie, MD | Baycrest | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Baycrest Health Sciences | Toronto | Ontario | M6A 2E1 | Canada |
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| ID | Term |
|---|---|
| D060825 | Cognitive Dysfunction |
| ID | Term |
|---|---|
| D003072 | Cognition Disorders |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |
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| OTHER |
| University Health Network, Toronto | OTHER |
| Michael Garron Hospital | OTHER |
| Centre for Addiction and Mental Health | OTHER |
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| Processing Speed Training | Behavioral | 9 weeks, a total of 10 hours of computer-based processing speed training; 60-75 minutes/week |
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| Brain Health Workshop | Behavioral | 9 weeks, 2 hour session/week, 1 hour/day homework (6 days/week), 2 x 0.5 hour sessions with trainer |
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| Useful Field of View Test (UFOV) | Visual field of view | 9-14 weeks, 33-38 weeks |
| Cognitive Failures Questionnaire | Absentmindedness, executive dysfunction in daily life | 9-14 weeks, 33-38 weeks |
| Dysexecutive Questionnaire | Absentmindedness, executive dysfunction in daily life | 9-14 weeks, 33-38 weeks |
| Geriatric Depression Scale (GDS-15 item) | Depressive symptoms | 9-14 weeks, 33-38 weeks |
| Quality of Life: AD (QOL-AD) | Quality of life with MCI and Alzheimer's disease | 9-14 weeks, 33-38 weeks |