This randomized clinical trial aims to investigate the effects of multicomponent concurrent exercise training associated or not with taurine supplementation on intramuscular fat infiltration, physical performance, transcriptomic profile, and metabolomic profile in older women with obesity. Forty women aged 60 to 75 years with obesity will be randomized into four groups: control, exercise, taurine, and exercise plus taurine. The intervention will last 16 weeks. Outcomes include magnetic resonance imaging, body composition, muscle biopsy, blood biomarkers, functional capacity tests, transcriptomic analysis, and metabolomic analysis.
Inclusion Criteria:
Exclusion Criteria:
Participants and outcome assessors will be blinded to taurine supplementation allocation. Taurine and placebo capsules will be identical in appearance.
Participants will not receive exercise training or taurine supplementation, only the placebo.
Participants will undergo supervised concurrent exercise training three times per week for 16 weeks and will receive placebo.
Participants will receive 3 grams per day taurine supplementation for 16 weeks.
Participants will undergo supervised multicomponent concurrent exercise training combined with 3 grams per day taurine supplementation for 16 weeks.
Ribeirão Preto, São Paulo 14040-900, Brazil
Taurine Supplementation and Training Effects on Energy Metabolism, Inflammation and Oxidative Stress in Obese Women
Metabolic and Molecular Responses Under the Effect of Taurine Supplementation With and Without Multicomponent Training
Plasma Taurine in Older Women With Obesity: Impact of Metabolic Phenotype and Combined Exercise
Taurine Supplementation Associated or Not With Exercise: Effect on Browning of White Adipose Tissue in Elderly Women With Sarcopenic Obesity
Taurine Supplementation and Exercise on Irisin Levels in Obesity
Effects of High-intensity Exercise With Hypoxia and Taurine Supplementation on Metabolic and Mitochondrial Parameters
Taurine as a Possible Anti-aging Therapy?
Effects Of Daily Taurine Intake For 6 Months On Biological Age and Body Metabolism Indicators As Well As Physical Fitness In 55-75-year-old Women And Men