Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| Stanford University | OTHER |
| Rutgers University | OTHER |
| Universitaet Innsbruck | OTHER |
| LMU Klinikum |
Not provided
Not provided
Not provided
The goal of this clinical trial is to investigate the effect of taking 4 grams of taurine by older adults on aging processes over a period of 6 months. It will also check for effects of taurine on participant's physical fitness, metabolic and cognitive functions. The main question it aims to answer is:
• Does a supplementation with 4 g of taurine daily over a period of 6 months slow down biological aging in humans? Researchers will compare supplementation with taurine to a placebo (a look-alike substance that contains no drug) to reliably determine whether taurine has an effect.
Participants will:
Measurements performed during study visits:
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 4g of taurine daily | Active Comparator | Intervention group (4g of taurine/day): 2g of taurine (4 capsules, 500mg each) in the morning and 2g of taurine (4 capsules, 500mg each) in the evening for 6 months |
|
| Placebo | Placebo Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| 4g of taurine daily | Dietary Supplement | Intervention group (4g of taurine/day): 2g of taurine (4 capsules, 500mg each) in the morning and 2g of taurine (4 capsules, 500mg each) in the evening for 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| Change From Baseline in Biological Age At 6 Months (Proteome Analysis) | The primary objective of the study is to answer the following research question: Does a 6-month supplementation with 4g of taurine daily slow down biological aging in humans? Biological age will be determined using a plasma proteome analysis and established machine learning models based on plasma and urine samples. This will also include an analysis of organ-specific aging. | pre-intervention (at time point 0) and post-intervention (at 24 weeks) |
| Change From Baseline in Biological Age At 6 Months (DNA Methylation) | The primary objective of the study is to answer the following research question: Does a 6-month supplementation with 4g of taurine daily slow down biological aging in humans? Biological age will be estimated by assessing DNA methylation patterns (epigenetic clock) from plasma, urine, and oral mucosa samples. | pre-intervention (at time point 0) and post-intervention (at 24 weeks) |
| Measure | Description | Time Frame |
|---|---|---|
| Change From Baseline In Cognitive Functions at 6 Months | Does a 6-month supplementation with 4 g of taurine daily influence parameters of mental health? Methods of measurement: MoCA (Montreal Cognitive Assessment) | pre-intervention (at time point 0) and post-intervention (after 24 weeks) |
| Change From Baseline In Cardiometabolic Risk Profile at 6 Months |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Institute for Nutritional Medicine of Technical University of Munich | Munich | 80992 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 38057571 | Background | Oh HS, Rutledge J, Nachun D, Palovics R, Abiose O, Moran-Losada P, Channappa D, Urey DY, Kim K, Sung YJ, Wang L, Timsina J, Western D, Liu M, Kohlfeld P, Budde J, Wilson EN, Guen Y, Maurer TM, Haney M, Yang AC, He Z, Greicius MD, Andreasson KI, Sathyan S, Weiss EF, Milman S, Barzilai N, Cruchaga C, Wagner AD, Mormino E, Lehallier B, Henderson VW, Longo FM, Montgomery SB, Wyss-Coray T. Organ aging signatures in the plasma proteome track health and disease. Nature. 2023 Dec;624(7990):164-172. doi: 10.1038/s41586-023-06802-1. Epub 2023 Dec 6. | |
| 37289866 |
Not provided
Not provided
IPD will not be shared because of data privacy and confidentiality.
Not provided
Not provided
Not provided
Not provided
Not provided
| OTHER |
Not provided
Not provided
Not provided
Not provided
| Placebo | Dietary Supplement | Controll group (4g of placebo/day): 2g of placebo (4 capsules, 500mg each) in the morning and 2g of placebo (4 capsules, 500mg each) in the evening for 6 months |
|
Does a 6-month supplementation with 4 g of taurine daily alter the cardiometabolic risk profile? Measurement: fasting blood glucose in mg/dL |
| pre-intervention (at time point 0) and post-intervention (at 24 weeks) |
| Change From Baseline In Cardiometabolic Risk Profile at 6 Months | Does a 6-month supplementation with 4 g of taurine daily alter the cardiometabolic risk profile? Measurement: Body-Mass-Index determined by participants weight in kilograms divided by height in metres squared. | pre-intervention (at time point 0) and post-intervention (at 24 weeks) |
| Change From Baseline In Cardiometabolic Risk Profile at 6 Months | Does a 6-month supplementation with 4 g of taurine daily alter the cardiometabolic risk profile? Measurement: blood pressure in mmHg | pre-intervention (at time point 0) and post-intervention (at 24 weeks) |
| Change From Baseline In Cardiometabolic Risk Profile at 6 Months | Does a 6-month supplementation with 4 g of taurine daily alter the cardiometabolic risk profile? Measurement: total cholesterol in mg/dl | pre-intervention (at time point 0) and post-intervention (at 24 weeks) |
| Change From Baseline In Cardiometabolic Risk Profile at 6 Months | Does a 6-month supplementation with 4 g of taurine daily alter the cardiometabolic risk profile? Measurement: LDL-cholesterol in mg/dL | pre-intervention (at time point 0) and post-intervention (at 24 weeks) |
| Change From Baseline In Cardiometabolic Risk Profile at 6 Months | Does a 6-month supplementation with 4 g of taurine daily alter the cardiometabolic risk profile? Measurement: HDL-cholesterol in mg/dL | pre-intervention (at time point 0) and post-intervention (at 24 weeks) |
| Change From Baseline In Cardiometabolic Risk Profile at 6 Months | Does a 6-month supplementation with 4 g of taurine daily alter the cardiometabolic risk profile? Measurement: C-reactive protein in mg/l | pre-intervention (at time point 0) and post-intervention (at 24 weeks) |
| Change From Baseline In Cardiometabolic Risk Profile at 6 Months | Does a 6-month supplementation with 4 g of taurine daily alter the cardiometabolic risk profile? Measurement: fasting insulin in pmol/l | pre-intervention (at time point 0) and post-intervention (at 24 weeks) |
| Change From Baseline In Handgrip Strength (kg) at 6 Months | Measurement of handgrip strength in kilograms and Newtons in the dominant hand using Jamar Hydraulic Hand Dynamometer. | pre-intervention (at time point 0) and post-intervention (at 24 weeks) |
| Change From Baseline In Physical Working Capacity (PWC130) At 6 Months | Measurement of heart rate (bpm) on the Corvial ergometer while increasing power manually by 25 W every 2 minutes. The endpoint is the power in Watts at the stage where heart rate of 130bpm is reached. | pre-intervention (at time point 0) and post-intervention (at 24 weeks) |
| Change From Baseline In Isometric Leg Extensor Strength For Each Leg At 6 Months | Measurement of leg extensor strength using a force transducer connected to the back of a chair and an ankle loop, as well as force recording software. The maximum force (N) will be multiplied with the distance from knee joint to the middle of the loop (in metres) to calculate the torque in Newton-metres (Nm) for each leg. | pre-intervention (at time point 0) and post-intervention (at 24 weeks) |
| Background |
| Singh P, Gollapalli K, Mangiola S, Schranner D, Yusuf MA, Chamoli M, Shi SL, Lopes Bastos B, Nair T, Riermeier A, Vayndorf EM, Wu JZ, Nilakhe A, Nguyen CQ, Muir M, Kiflezghi MG, Foulger A, Junker A, Devine J, Sharan K, Chinta SJ, Rajput S, Rane A, Baumert P, Schonfelder M, Iavarone F, di Lorenzo G, Kumari S, Gupta A, Sarkar R, Khyriem C, Chawla AS, Sharma A, Sarper N, Chattopadhyay N, Biswal BK, Settembre C, Nagarajan P, Targoff KL, Picard M, Gupta S, Velagapudi V, Papenfuss AT, Kaya A, Ferreira MG, Kennedy BK, Andersen JK, Lithgow GJ, Ali AM, Mukhopadhyay A, Palotie A, Kastenmuller G, Kaeberlein M, Wackerhage H, Pal B, Yadav VK. Taurine deficiency as a driver of aging. Science. 2023 Jun 9;380(6649):eabn9257. doi: 10.1126/science.abn9257. Epub 2023 Jun 9. |
| ID | Term |
|---|---|
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D001519 | Behavior |
Not provided
Not provided