Dietary Supplements and Middle Aged Women (Creatine) | NCT07729930

NCT07729930

Overview

NCT ID: NCT07729930
Lead Sponsor: Loughborough UniversityOTHER
Official Title: The Effects of Dietary Supplements on Health and Wellbeing in Middle Aged Women
Brief Summary: This study will examine the effects of combining different types of dietary supplements on various aspects of health and wellbeing in middle aged women. The main outcomes of the trial will be aspects of health and wellbeing that middle aged women report as increasingly problematic, such as joint pain, fatigue, sleep, and changes in body composition, strength, and inflammation. Participants will consume the supplement(s) or placebo for 8 weeks, and outcome measures will be assessed before and after supplementation.
Conditions: Cognition
Muscle Strength
Fatigue Symptom
Blood Pressure and Augmentation Index
Body Composition Changes

Status and Timeline

Status: Recruiting
Last Update Posted: Jul 28, 2026Actual
Start Date: May 1, 2026Actual
Primary Completion Date: Nov 1, 2028Estimated
Completion Date

Participation Criteria

Ages Eligible for Study: Adult (18-64)Older Adult (65+)
Sexes Eligible for Study: Female
Accepts Healthy Volunteers?: Yes
Eligibility Criteria: Inclusion Criteria:

Female

Aged 35-65 years old

Healthy, free from known disease

Non-smoker

BMI 18-30 kg/m2

Classified as recreationally active (meet the WHO guidelines for physical activity: complete at least 150-300 minutes of moderate intensity activity or 75-150 minutes of vigorous intensity activity a week, plus muscle strengthening activities 2 or more days a week) OR sedentary (do not meet the minimum activity guidelines but do occasional and/or incidental physical activity, e.g., walking to work, household activities).

Exclusion Criteria:

Currently have a musculoskeletal injury or diagnosed condition (CVD, osteoarthritis, diabetes, cancer, metabolic syndrome, uncontrolled hypertension, gastrointestinal disease, blood clotting disorder)

Regularly taking prescription medication initiated in the last 3 months or unstable

Have initiated hormone replacement therapy within the last 3 months or unstable

Have an allergy to ingredients in the supplements or standardised breakfast

Pregnant or breastfeeding, or any other contradictions to consuming the study supplements

Lost more than 10% of body mass in the past 6 months or plan on trying to lose body mass during trial period

Currently consuming the supplements being investigated and unwilling to stop

Any known cognitive or visual impairments limiting ability to perform cognitive tests

Unwilling to maintain current diet and physical activity levels and report any change in health status

Study Plan

Study Type: Interventional
Phase: Not Applicable
Enrollment: 38Estimated
Primary Purpose: Treatment
Allocation: Randomized
Interventional Model: Parallel Assignment
Masking: Triple

Contacts and Locations

Central Contacts: Dr Tom CliffordContact
t.clifford@lboro.ac.uk+44 (0) 1509228181

Overview

Status and Timeline

Participation Criteria

Study Plan

Contacts and Locations

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