BIOANCIENT_EX: Effects of a Physical Exercise Program in Centenarians of the BIOANCIENT Cohort: A Randomized Clinical Trial. | NCT07723339

NCT07723339

Overview

NCT ID: NCT07723339
Lead Sponsor: Fundacion Miguel ServetOTHER
Official Title: BIOANCIENT_EX: Effects of a Physical Exercise Program in Centenarians of the BIOANCIENT Cohort: A Randomized Clinical Trial.
Brief Summary: This study aims to evaluate the effects of a home intervention of individualized multicomponent physical exercise program (including strength, balance, flexibility, and mobility training) on functional health, physical capacity, and biological markers in centenarians. The intervention includes periodic monitoring and individualized exercise progression every three weeks.
Conditions: Aging
Cellular Senescence
Biomarkers / Blood
Exercise
Frailty

Status and Timeline

Status: Active, not recruiting
Last Update Posted: Jul 23, 2026Actual
Start Date: Jun 12, 2026Actual
Primary Completion Date: Dec 2027Estimated
Completion Date

Participation Criteria

Ages Eligible for Study: Older Adult (65+)
Sexes Eligible for Study: All
Accepts Healthy Volunteers?: No
Eligibility Criteria: Inclusion Criteria:

Individuals aged ≥ 100 years;

Residents of Navarre.;

Barthel Index score ≥ 60, capable of standing and performing transfers independently or with minimal assistance;

Stable clinical condition;

Ability to follow simple instructions;

Signed informed consent (by the participant or legal representative).

Exclusion Criteria:

Acute illness or unstable chronic condition, clinical decompensation within the last month: hemodynamic instability, acute pathology, hospitalization;

Severe cardiovascular or respiratory pathology that contraindicates exercise;

Severe cognitive impairment preventing participation;

Recent fracture or major surgery (< 3 months).

Individuals in an end-of-life situation, defined as a clinical state of irreversible decline with a life expectancy of less than weeks or months, according to medical criteria.

Study Plan

Study Type: Interventional
Phase: Not Applicable
Enrollment: 60Estimated
Primary Purpose: Prevention
Allocation: Randomized
Interventional Model: Parallel Assignment
Masking: None (Open Label)

Contacts and Locations

Central Contacts: No data available
Locations: Navarrabiomed

Similar Studies

Participant Group/Arms

ControlNo Intervention

Participants assigned to the control group will receive usual care and will not undergo any specific intervention related to individualized multicomponent exerceise. They will continue doing their daily routine.

ExerciseExperimental

Participants in this group will take part in a individualized multicomponent physical training program including exercises targeting strength, balance, and aerobic capacity, adapted to centenarians and conducted following established safety guidelines.

Other: Exercise