Not provided
| ID | Type | Description | Link |
|---|---|---|---|
| R01AG089150 | U.S. NIH Grant/Contract | View source |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| National Institute on Aging (NIA) | NIH |
| Tufts University Jean Mayer USDA Human Nutrition Research Center on Aging | OTHER |
Not provided
Not provided
Not provided
Not provided
To critically examine biological, clinical, and behavioral modulators of progressive resistance training-associated exercise response heterogeneity in physical function and whole-body metabolism in older adults.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Progressive Resistance Training | Other | participants will attend exercise session 3 times per week. |
|
| Health Education | Other | participants will attend health educations classed 1 time per week. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Progressive Resistance Training | Other | 3 times a week |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Precisely define the variability in changes in physical function | Measured by the Short Physical Performance Battery (SPPB), a 0-12 categorical scale of walking speed, standing balance, and repeated sit-to-stand time, with higher scores reflecting better physical function. | baseline, 6 months |
| Precisely define the variability in changes in blood glucose concentrations in response to a meal tolerance test | Blood glucose concentrations (millimoles/liter) will be measured in response to a physiologically relevant meal challenge. Lower values are indicative of better metabolic health. | baseline, 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| Precisely define the variability in changes in skeletal muscle size. | Measured by computed tomography scans of the mid-thigh. Larger muscle cross-sectional area (cm^2) reflects a greater quantity of skeletal muscle. | baseline, 6 months |
| Precisely define the variability in changes in skeletal muscle strength. |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Amanda Tweed | Contact | 507-255-6663 | tweed.amanda@mayo.edu |
| Name | Affiliation | Role |
|---|---|---|
| Nathan LeBrasseur, Ph.D, MS | Mayo Clinic | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University | Recruiting | Boston | Massachusetts | 02111 | United States |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D001519 | Behavior |
Not provided
Not provided
Progressive Resistance Training vs. Health Education
Not provided
Not provided
Data analysis team
| Health Education |
| Other |
once a week |
|
Measured by the one-repetition maximum, in newtons, on a leg press device, with higher scores reflecting greater skeletal muscle strength. |
| baseline, 6 months |
| Precisely define the variability in changes in six-minute walk distance. | Measured by the distance (meters) walked in six minutes, with longer distances reflecting better physical function. | baseline, 6 months |
| Precisely define the variability in insulin secretion in response to a mixed meal tolerance test. | Blood insulin concentrations (pmol/L) will be measured in response to a physiologically relevant meal challenge. Insulin concentrations in a physiological range reflect better metabolic health, while low insulin concentrations can reflect an impaired insulin response and high insulin concentrations can reflect peripheral insulin resistance. | baseline, 6 months |
| Precisely define the variability in changes in the percentage of glycated hemoglobin in the blood. | Measured by the percentage of glycated hemoglobin in the blood (often referred to as HbA1c). A lower percentage of HbAlc reflects lower blood glucose concentrations over the past two to three months. | baseline, 6 months |
| Precisely define the variability in changes in blood lipids. | Blood lipids, including total cholesterol, low density lipoproteins (LDLs), high density lipoproteins (HDLs), and triglycerides will be measured. Lower levels of total cholesterol (mg/dL), LDLs (mg/dL), and triglycerides (mg/dL), and higher levels of HDLs (mg/dL), are reflective of better metabolic health. | baseline, 6 months |
| Precisely define the variability in changes in waist-to-hip ratio. | The circumference (cm) of the waist and hips will be measured and a ratio will be calculated. A lower waist-to-hip ratio is reflective of a better body composition (less central obesity or visceral fat). | baseline, 6 months |
| Mayo Clinic | Recruiting | Rochester | Minnesota | 55905 | United States |
|