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| Name | Class |
|---|---|
| National Health Research Institutes, Taiwan | OTHER |
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This project aims to investigate the intricate interplay between skeletal muscle and adipose tissue during the aging process by integrating human studies. Utilizing interventional research and randomized trials combined with examining blood samples from elderly individuals engaged in exercise, we aim to investigate the effects of exercise on muscle health and explore the underlying mechanisms of muscle aging and related biomarkers. Interdisciplinary research allowed us to investigate the systemic impact of exercise on muscles. This approach allowed us to gain a better understanding of the interconnectedness of skeletal muscle and adipose tissue in the aging process and devise efficient strategies to reverse age-related changes. These findings hold promise for promoting a future society where long and healthy life is achievable for all.
This study is a randomized controlled trial of 6-month multidomain intervention program among community-living older adults with early physical impairments.
Inclusion criteria are: (1) community-dwelling adults aged ≥ 65 years, (2) slow gait speed (<1 m/s in 6-meter walk test) or weakness (dominant handgrip strength <28 kg in men, <18 kg in women); subjects with the following conditions will be excluded: (1) established diagnosis of dementia, Parkinsonism or other neurodegenerative disease (2) disable status: mobilitylimiting conditions, (3) active, acute diseases receiving treatment, such as cancer, heart failure, COPD and so on, (4) estimated life expectancy <12 months, (5) current nursing home residents.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Multidomain intervention group | Experimental | The multidomain intervention program is designed as structural training sessions of 2-hour training sessions two times per week. |
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| Usual care group | No Intervention | Provide conventional health educations in every three-month interval |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Multi-domain intervention | Behavioral | Each session comprises of 45 minutes physical fitness activities targeting on muscle strength, balance, and flexibility; 1-hour cognitive training primarily on reasoning and memory exercises; and 15-minute for nutritional advices based on national diet guidelines for older adults |
| Measure | Description | Time Frame |
|---|---|---|
| Change in Physical performance | Change in hand-grip strength (kg), or six-meter walking speed (m/s), or 5 times sit to stand test from baseline to 6 months in all participants | baseline, 6 month |
| Measure | Description | Time Frame |
|---|---|---|
| Change in DHEA-S | Change in DHEA-S concentration from baseline to 6 months in all participants | baseline, 6 month |
| Change in IGF-1 | Change in IGF-1 concentration from baseline to 6 months in all participants |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Li-Ning Peng, M.D., PhD | Contact | +886-28239014 | lining.peng@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Li-Ning Peng, M.D., PhD | Center for Healthy Longevity and Aging Sciences, National Yang Ming Chiao Tung University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Center for Healthy Longevity and Aging Sciences, National Yang Ming Chiao Tung University | Recruiting | Taipei | 112 | Taiwan |
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| baseline, 6 month |
| Change in hs-CRP | Change in hs-CRP concentration from baseline to 6 months in all participants | baseline, 6 month |
| Change in Myostatin | Change in Myostatin concentration from baseline to 6 months in all participants | baseline, 6 month |
| Change in Activing A | Change in Activing A concentration from baseline to 6 months in all participants | baseline, 6 month |
| Change in Follistatin | Change in Follistatin concentration from baseline to 6 months in all participants | baseline, 6 month |
| Change in Relative appendicular skeletal muscle index (RASM) | Change in RASM from baseline to 6 months in all participants | baseline, 6 month |
| Change in body fat % | Change in body fat % from baseline to 6 months in all participants | baseline, 6 month |
| Change in Cognitive performance | Change in Montreal Cognitive Assessment (MoCA), or Mini-mental state examination (MMSE) from baseline to 6months in all participants | baseline, 6 month |
| Change from lipoproflie | Change in Total Cholesterol, Triglyceride, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol from baseline to 6months in all participants | baseline, 6 month |