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1. To develop a multiactivity training programme. 2. To explore the effect of this programme on sarcopenia, sarcopenic obesity, cognitive impairment and Parkinson's disease. 3. To compare the effects of the experimental and control treatments on the muscle strength, body composition, physical function performance and quality of life of the elderly.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| muscle strength training and protein supplementation | Experimental |
| |
| usual care | Placebo Comparator |
| |
| muscle strength training | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| protein supplementation | Dietary Supplement | protein supplementation for 16 weeks |
|
| Measure | Description | Time Frame |
|---|---|---|
| Chang in muscle strength from baseline to 16 weeks | pinch, grip and quadriceps strength. A Higher score means a better outcome. | Baseline and 16 weeks |
| Chang in weight of muscle and fat from baseline to 16 weeks | muscle mass(kg), fat mass (kg) | Baseline and 16 weeks |
| Chang in Activities of Daily Living from baseline to 16 weeks | This is a scale of physical function. The range for total score is 0-100. A Higher score means a worse outcome. | Baseline and 16 weeks |
| Chang in Instrumental activities of daily living from baseline to 16 weeks | This is a scale of physical function. The range for total score is 0-24. A Higher score means a better outcome. | Baseline and 16 weeks |
| Chang in Clinical Dementia Rating from baseline to 16 weeks | Mental Function Assessment. The range is 0-3. A Higher score means a worse outcome. | Baseline and 16 weeks |
| Chang in Cornell Scale for Depression in Dementia from baseline to 16 weeks | Mental Function Assessment. The range for total score is 0-38. A Higher score means a worse outcome. | Baseline and 16 weeks |
| Chang in Cohen-Mansfield Agitation Inventory from baseline to 16 weeks | This is a scale of behavior measurement. The range for total is 29-203. A higher score means a worse outcome. |
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Inclusion Criteria:
(1) over 60 years old, (2) able to Communicate and follow instructions; (3) Stable condition with sufficient physical strength: able to maintain a seated position in a wheelchair or on the edge of a bed for at least one hour. (4) sarcopenia, sarcopenic obesity, cognitive impairment and Parkinson's disease.
Exclusion Criteria:
(1) difficulty in standing or walking and obvious musculoskeletal disease, (2) unsuitable for diagnosis by a physician those engaged in sports activities, (3) serious diseases/unstable states, such as severe heart, lung, liver and kidney diseases, severe malignant tumors, severe nutrition poor, severe dementia, (4) more than 180 minutes of exercise per week in the past month, (5) no willingness to participate.
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| Name | Affiliation | Role |
|---|---|---|
| Chiu | Central Taiwan University of Science and Technology | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Daycare center at Central Taiwan University of Science and Technology | Taichung | Taiwan |
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| ID | Term |
|---|---|
| D055948 | Sarcopenia |
| D003704 | Dementia |
| ID | Term |
|---|---|
| D009133 | Muscular Atrophy |
| D020879 | Neuromuscular Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
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| muscle strength training | Behavioral | muscle strength training for 16 weeks |
|
| usual care | Other | no intervention |
|
| Baseline and 16 weeks |
| Chang in EQ5D from baseline to 16 weeks | This is a scale of quality of life. The range for total is 0-20. A higher score means a worse outcome. | Baseline and 16 weeks |
| Chang in QUALIDEM from baseline to 16 weeks | The scale is a dementia-specific Qol instrument. The range for total score is 0-120. A higher score means a better outcome. | Baseline and 16 weeks |
| Demographic attributes | Gender, education, age, married status, religion, medication, diseases, work and height. | Baseline |
| Chang in PERSONAL WELLBEING INDEX from baseline to 16 weeks | The range for total is 0-80. A higher score means a better outcome. | Baseline and 16 weeks |
| Chang in PERSONAL WELLBEING INDEX intellectual disability from baseline to 16 weeks | The range for total is 0-70. A higher score means a better outcome. | Baseline and 16 weeks. |
| Chang in World Health Organization Quality of Life Instruments (WHOQOL-BREF) from baseline to 16 weeks | This is a scale of quality of life. The range for total is 26-130. A higher score means a better outcome. | Baseline and 16 weeks. |
| Chang in Four-Meter Gait Speed from baseline to 16 weeks | Measured with seconds. A higher score means a worse outcome. | Baseline and 16 weeks. |
| D001284 | Atrophy |
| D020763 | Pathological Conditions, Anatomical |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012816 | Signs and Symptoms |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |