The Effect of Using Different Scaffolds in Retreated Teeth on The Clinical and Radiological Success of Regenerative Endodontic Treatment | NCT07721051

NCT07721051

Overview

NCT ID: NCT07721051
Lead Sponsor: Kırıkkale UniversityOTHER
Official Title: The Effect of Using Different Scaffolds in Retreated Teeth on The Clinical and Radiological Success of Regenerative Endodontic Treatment
Brief Summary: This clinical study aims to compare the clinical and radiographic outcomes of four different scaffolds used in regenerative endodontic treatment of previously root canal-treated permanent teeth requiring retreatment.

Participants will be randomly assigned to one of four groups based on the scaffold used: induced blood clot, injectable platelet-rich fibrin (i-PRF), advanced platelet-rich fibrin (A-PRF), or advanced platelet-rich fibrin plus (A-PRF+). All participants will receive the same root canal disinfection and restorative procedures, with the scaffold type differing between the groups.

Participants will be evaluated clinically and radiographically at 3, 6, and 12 months after treatment. The study will compare the groups in terms of the resolution of clinical signs and symptoms and changes observed on radiographic and cone-beam computed tomography images.
Conditions

Status and Timeline

Status: Not yet recruiting
Last Update Posted: Jul 22, 2026Actual
Start Date: Oct 1, 2026Estimated
Primary Completion Date: Dec 1, 2027Estimated
Completion Date

Participation Criteria

Ages Eligible for Study: Child (0-17)Adult (18-64)
Sexes Eligible for Study: All
Accepts Healthy Volunteers?: No
Eligibility Criteria: Inclusion Criteria:

Patients aged 16-40 who are systemically healthy

Patients who have a permanent tooth with a single root canal and fully developed root that requires retreatment

Patients who may or may not have periapical radiolucency

Exclusion Criteria:

Patients who require antibiotic prophylaxis

Patients with systemic conditions such as diabetes or hematological disorders

Patients who have taken antibiotics, anti-inflammatory medications, and/or antidepressants within the past three weeks

Patients who are pregnant or suspect they may be pregnant during treatment

Patients with heavy plaque and tartar buildup on their teeth

Patients with redness and bleeding of the gums

Patients with severe gingivitis, generalized periodontitis, or a periodontal pocket depth of more than 3 mm

Patients with internal or external root resorption

Patients for whom complete isolation with a rubber dam cannot be achieved

Patients with an open, immature root apex

Patients with horizontal or vertical fractures

Patients with teeth having multiple roots or root canals

Study Plan

Study Type: Observational
Phase: No data available
Enrollment: 60Estimated
Primary Purpose: No data available
Allocation: No data available
Interventional Model: No data available
Masking: No data available

Contacts and Locations

Central Contacts: ALİ ERDEMİR, ProfessorContact
erdemirali@hotmail.com+905325650065

Similar Studies

Participant Group/Arms

Blood clot group

Bleeding will be induced by removing the apical opening with sterile Type K files to ensure the canal fills with blood. The blood clot induced apically will be used as the scaffold material.

i-PRF group

10 cc of venous blood drawn from the patient's antecubital vein will be centrifuged at 700 rpm for 3 minutes. The yellow layer on top will be drawn up with a syringe and injected into the canal. i-PRF will be used as the scaffold material.

A-PRF group

The 10 cc of venous blood obtained as in Group 2 will be centrifuged at 1500 rpm for 14 minutes. The yellow layer on top will be removed from the tube and applied into the canal using sterile applicators. A-PRF will be used as the scaffold material.

A-PRF+ group

As in Group 2, 10 cc of venous blood will be centrifuged at 1300 rpm for 8 minutes. The yellow layer on top will be removed from the tube and applied into the canal using sterile pluggers. A-PRF+ will be used as the scaffold material.