Evaluation of Different Scaffolds in Regenerative Endodontic Treatment

Evaluation of Different Scaffolds in Regenerative Endodontic Treatment of Immature Non-Vital Permanent Teeth and Their Release of Growth Factors: A Randomized Clinical Trial

The aim of this study is to evaluate and compare the regenerative potentials of Injectable Platelet-Rich Fibrin (I-PRF), Platelet-Rich Fibrin (PRF), and Blood Clot (BC) as different scaffolds regarding:

Radiographic outcomes (increase of root length, increase in thickness of dentinal wall, healing of periapical lesion, and apical closure).

Clinical outcomes in the treatment of young, immature permanent teeth with necrotic pulps.

Inclusion Criteria:

• Necrotic immature permanent anterior teeth.
• Teeth not indicated for post/core final restoration.
• Radiographically: The root has incomplete development with an apical opening of more than 1 mm.

Exclusion Criteria:

• Medically compromised patients with blood and immunity disorders. Family history of autoimmune disorder. Also, patients with physical or mental handicapping conditions.
• Teeth with questionable restorability of the remaining crown/root structure.
• Pathological tooth mobility.
• Radiographically: Evidence of root fracture or root resorption (external or internal).