Phacovitrectomy Versus Pars Plana Vitrectomy Alone for Post-Intravitreal Injection Endophthalmitis | NCT07717944

NCT07717944

Overview

NCT ID: NCT07717944
Lead Sponsor: Benha UniversityOTHER
Official Title: Outcomes of Phacovitrectomy Versus Pars Plana Vitrectomy Alone in Patients With Post-Intravitreal Injection Endophthalmitis: A Retrospective Comparative Cohort Study
Brief Summary: This prospective comparative interventional study evaluated the anatomical and visual outcomes of phacovitrectomy versus pars plana vitrectomy (PPV) alone in patients with post-intravitreal injection endophthalmitis. Eligible patients underwent either combined phacovitrectomy or PPV alone according to the study protocol. The primary outcome was the change in best-corrected visual acuity (BCVA) from baseline to 3 months after surgery. Secondary outcomes included postoperative complications, need for additional surgical intervention, resolution of intraocular inflammation, and restoration of media clarity.
Conditions: Endophthalmitis
Endophthalmitis Postoperative

Status and Timeline

Status: Completed
Last Update Posted: Jul 21, 2026Actual
Start Date: Jan 15, 2024Actual
Primary Completion Date: Jun 19, 2026Actual
Completion Date

Participation Criteria

Ages Eligible for Study: Child (0-17)Adult (18-64)Older Adult (65+)
Sexes Eligible for Study: All
Accepts Healthy Volunteers?: No
Eligibility Criteria: Inclusion Criteria:

Adults aged 18 years or older.

Clinical diagnosis of acute post-intravitreal injection infectious endophthalmitis.

History of intravitreal injection before the onset of endophthalmitis.

Phakic eye at the time of presentation.

Eyes with persistent or worsening clinical signs despite initial intravitreal antibiotic therapy (vancomycin and ceftazidime), requiring surgical intervention.

Underwent either combined phacovitrectomy or pars plana vitrectomy alone as the primary surgical treatment.

Ability to complete at least 3 months of postoperative follow-up.

Exclusion Criteria:

Endophthalmitis secondary to causes other than intravitreal injection (e.g., post-cataract surgery, glaucoma surgery, penetrating ocular trauma, or endogenous endophthalmitis).

Previous vitrectomy in the study eye.

Pre-existing ocular conditions likely to significantly affect visual outcomes, including retinal detachment, advanced optic neuropathy, advanced glaucoma, or dense corneal opacity.

Eyes with no visual potential before the onset of endophthalmitis.

Inability to complete the scheduled follow-up visits or missing primary outcome data.

Study Plan

Study Type: Interventional
Phase: Not Applicable
Enrollment: 40Actual
Primary Purpose: Treatment
Allocation: Randomized
Interventional Model: Parallel Assignment
Masking: None (Open Label)

Contacts and Locations

Central Contacts: No data available
Locations: Benha University

Similar Studies

Participant Group/Arms

PhacovitrectomyExperimental

Twenty participants with post-intravitreal injection endophthalmitis underwent combined phacoemulsification with intraocular lens implantation and pars plana vitrectomy as the primary surgical treatment. Standard intravitreal antibiotics were administered according to the study protocol when indicated.

Procedure: Phacovitrectomy

Pars Plana Vitrectomy AloneActive Comparator

Twenty participants with post-intravitreal injection endophthalmitis underwent pars plana vitrectomy alone as the primary surgical treatment. Standard intravitreal antibiotics were administered according to the study protocol when indicated.

Procedure: Pars plana vitrectomy