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Visual impairment, whether central or peripheral, may influence the plasticity of other sensory modalities, such as taste and smell. Taste-evoked potentials (TEPs) and smell-evoked potentials (SEPs)-methods for analyzing brain activity in response to taste and smell stimuli-allow for the objective assessment of these interactions. This approach has already demonstrated its value in the study of cognitive disorders. This study aims to demonstrate an enhancement of taste and smell capabilities that could compensate for specific visual impairments, particularly in situations involving food choices.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients with retinal dystrophy and central or peripheral visual field defects | Other |
| |
| Healthy volunteers | Other |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Taste and smell evaluation | Other | Determination of taste and smell ability scores using standardized methods (ETOC and Taste Strips) |
|
| Measure | Description | Time Frame |
|---|---|---|
| Average latency of PEG (Taste-Evoked Potentials) peaks | Measurement of the mean latency of taste-evoked potential peaks in visually impaired patients versus control subjects following purely gustatory stimulation (sucrose). | At the baseline |
| Average amplitude of PEG (Taste-Evoked Potentials) peaks | Measurement of the mean amplitude of taste-evoked potential peaks in visually impaired patients versus control subjects following purely gustatory stimulation (sucrose). | At the baseline |
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Inclusion Criteria:
A. Central: documented bilateral macular dystrophy (e.g., Stargardt disease, Best disease) with confirmed central scotoma (CV 24.2, 10.2, or 30.2).
B. Peripheral: documented bilateral peripheral retinal dystrophy with confirmed peripheral involvement (CV 30-2 or 24-2).
• Control group: a person with normal vision and no known ophthalmological abnormalities (normal visual acuity and fundus examination) who is precisely matched by sex and smoking status (former smoker who has quit vs. nonsmoker), and approximately matched by age (± 5 years) to a visually impaired participant included in the study.
Exclusion Criteria:
For this group: patients with visual impairments:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Pierre-Henry GABRIELLE | Contact | 03.80.29.37.56 | +33 | pierrehenry.gabrielle@chu_dijon.fr |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Chu Dijon Bourgogne | Dijon | 21000 | France |
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| Recording of evoked potentials (EP) | Other | A recording of gustatory evoked potentials (GEP) and olfactory evoked potentials (OEP) in response to stimuli consisting of sucrose solution, vanillin, and a combination of the two. |
|
| ID | Term |
|---|---|
| D019575 | Blindness, Cortical |
| ID | Term |
|---|---|
| D001766 | Blindness |
| D014786 | Vision Disorders |
| D012678 | Sensation Disorders |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D005128 | Eye Diseases |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D013649 | Taste |
| ID | Term |
|---|---|
| D012677 | Sensation |
| D009424 | Nervous System Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
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