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The aim of the PI-PEG study is to explore the taste functions of the following 3 groups of participants:
To this end, the results obtained from taste evoked potentials in each of the 3 groups of participants will be compared with each other and with different nutritional, motor and cognitive data.
This study could reveal a difference in cortical processing of gustatory sensory information between patients who have had idiopathic Parkinson's disease progressing for 3 years or less, and patients who have had Lewy body disease progressing for 3 years or less. Indeed, a modification of taste evoked potentials (in terms of latencies) proportional to the degree of cerebral degeneration could be observed.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Healthy volunteers | Active Comparator |
| |
| Patients with Idiopathic Parkinson's Disease (IPD) of course ≤ 3 years | Experimental |
| |
| Patients with Lewy body disease (LBD) progressing ≤ 3 years | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Fasting blood test | Biological | metabolic assays determination of food intake hormones oxidative stress and neurodegeneration marker assays |
|
| Measure | Description | Time Frame |
|---|---|---|
| Average latency of taste-evoked potentials | After a 2-hour fasting period |
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Inclusion Criteria:
Healthy volunteers:
Patients with idiopathic Parkinson's disease:
Patients with Lewy body disease:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Vincent SCHNEIDER | Contact | 03.80.29.30.89 | vincent.schneider@chu-dijon.fr |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Chu Dijon Bourgogne | Recruiting | Dijon | France |
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| Subject interview | Other | socio-demographic data, medical and family history, treatment taken |
|
| Motor assessment | Other | MDS-UPDRS scale PART III |
|
| Neurocognitive assessment | Other | MoCA and MMSE scales |
|
| Nutritional assessment | Other | anthropometric data (weight, height, BMI, waist circumference, hip circumference, android/gynoid ratio, triceps skin fold, brachial circumference), bioelectrical impedancemetry (fat mass, lean mass, water mass and bone mass) |
|
| Taste tests | Other | Recording of PEGs in response to a sucrose solution and a free fatty acid solution (prepared beforehand) |
|
| ID | Term |
|---|---|
| D010300 | Parkinson Disease |
| D020961 | Lewy Body Disease |
| ID | Term |
|---|---|
| D020734 | Parkinsonian Disorders |
| D001480 | Basal Ganglia Diseases |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D009069 | Movement Disorders |
| D000080874 | Synucleinopathies |
| D019636 | Neurodegenerative Diseases |
| D003704 | Dementia |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |
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| ID | Term |
|---|---|
| D000073216 | Mental Status and Dementia Tests |
| D015596 | Nutrition Assessment |
| ID | Term |
|---|---|
| D009483 | Neuropsychological Tests |
| D011581 | Psychological Tests |
| D004191 | Behavioral Disciplines and Activities |
| D003625 | Data Collection |
| D004812 | Epidemiologic Methods |
| D008919 | Investigative Techniques |
| D017531 | Health Care Evaluation Mechanisms |
| D011787 | Quality of Health Care |
| D017530 | Health Care Quality, Access, and Evaluation |
| D015991 | Epidemiologic Measurements |
| D011634 | Public Health |
| D004778 | Environment and Public Health |
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